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Literature summary extracted from

  • Cheng, T.L.; Wu, Y.T.; Lin, H.Y.; Hsu, F.C.; Liu, S.K.; Chang, B.I.; Chen, W.S.; Lai, C.H.; Shi, G.Y.; Wu, H.L.
    Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing (2011), J. Invest. Dermatol., 131, 2486-2494.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.105 3,4-dichloroisocoumarin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.105 thrombomodulin + H2O Homo sapiens
-
 soluble thrombomodulin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.105 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.105 HaCaT cell
-
 Homo sapiens
-
3.4.21.105 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.105 thrombomodulin + H2O
-
 Homo sapiens soluble thrombomodulin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.105 RHBDL2
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.105 Homo sapiens rhombopid protease RHBDL2 is upregulated in HaCaT cells stimulated by scratch wounds. RHBDL2 is also upregulated in ex vivo tissue culture of the injured skin (3-5 days after incision) up

General Information

EC Number General Information Comment Organism
3.4.21.105 malfunction inhibition of RHBDL2 by 3,4-dichloroisocoumarin or short hairpin RNA significantly inhibits wound-induced thrombomodulin ectodomain shedding and wound healing Homo sapiens
3.4.21.105 physiological function RHBDL2 is required for wound recovery, cell migration, and proliferation Homo sapiens