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Literature summary extracted from

  • Laarman, A.J.; Bardoel, B.W.; Ruyken, M.; Fernie, J.; Milder, F.J.; van Strijp, J.A.; Rooijakkers, S.H.
    Pseudomonas aeruginosa alkaline protease blocks complement activation via the classical and lectin pathways (2012), J. Immunol., 188, 386-393.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.40 human complement component C1 + H2O Pseudomonas aeruginosa
-
 ?
-
 ?
3.4.24.40 human complement component C2 + H2O Pseudomonas aeruginosa
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.40 Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.40 human complement component C1 + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
3.4.24.40 human complement component C2 + H2O
-
 Pseudomonas aeruginosa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.40 AprA
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 Pseudomonas aeruginosa
3.4.24.40 Pseudomonas aeruginosa alkaline protease
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 Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
3.4.24.40 physiological function the alkaline protease AprA is associated with bacterial virulence and interferes with complement-mediated lysis of erythrocytes and complement activation. AprA potently blocks phagocytosis and killing of Pseudomonas by human neutrophils. AprA inhibits opsonization of bacteria with C3b and the formation of the chemotactic agent C5a. AprA specifically blocks C3b deposition via the classical and lectin pathways, whereas the alternative pathway is not affected. AprA degrades both human C1s and C2, and the mechanism of action for complement inhibition is cleavage of C2, overview Pseudomonas aeruginosa