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Literature summary extracted from

  • Jiang, R.; Shi, Z.; Johnson, J.J.; Liu, Y.; Stack, M.S.
    Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma (2011), J. Biol. Chem., 286, 9127-9135.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B39 chymostatin
-
 Homo sapiens
3.4.21.B39 leupeptin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B39 desmoglein 1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B39 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B39 keratinocyte cell line pre-malignant keratinocyte cell line Homo sapiens
-
3.4.21.B39 OKF-6 cell
-
 Homo sapiens
-
3.4.21.B39 oral squamous cell carcinoma cell
-
 Homo sapiens
-
3.4.21.B39 SCC-25 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B39 desmoglein 1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B39 kallikrein-5
-
 Homo sapiens
3.4.21.B39 KLK5
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.B39 Homo sapiens expression of kallikrein 5 is higher in oral squamous cell carcinoma cell compared to pre-malignant cells up

General Information

EC Number General Information Comment Organism
3.4.21.B39 malfunction knockdown of kallikrein-5 expression reduces processing of desmoglein 1 Homo sapiens
3.4.21.B39 physiological function kallikrein-5 promotes metastatic dissemination of oral squamous cell carcinoma cells by promoting loss of junctional integrity through cleavage of desmoglein 1 Homo sapiens