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Literature summary extracted from

  • Gambliel, H.; Croteau, R.
    Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration (1984), J. Biol. Chem., 259, 740-748.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.116 4-hydroxymercuribenzoate
-
 Salvia officinalis
4.2.3.116 diphosphate
-
 Salvia officinalis
4.2.3.116 N-ethylmaleimide
-
 Salvia officinalis
4.2.3.117 4-hydroxymercuribenzoate
-
 Salvia officinalis
4.2.3.117 diphosphate
-
 Salvia officinalis
4.2.3.117 N-ethylmaleimide
-
 Salvia officinalis
4.2.3.119 4-hydroxymercuribenzoate
-
 Salvia officinalis
4.2.3.119 diphosphate
-
 Salvia officinalis
4.2.3.119 N-ethylmaleimide
-
 Salvia officinalis
4.2.3.120 4-hydroxymercuribenzoate
-
 Salvia officinalis
4.2.3.120 diphosphate
-
 Salvia officinalis
4.2.3.120 N-ethylmaleimide
-
 Salvia officinalis
4.2.3.121 4-hydroxymercuribenzoate
-
 Salvia officinalis
4.2.3.121 diphosphate
-
 Salvia officinalis
4.2.3.121 N-ethylmaleimide
-
 Salvia officinalis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.3.116 soluble
-
 Salvia officinalis
-
-
4.2.3.117 soluble
-
 Salvia officinalis
-
-
4.2.3.119 soluble
-
 Salvia officinalis
-
-
4.2.3.120 soluble
-
 Salvia officinalis
-
-
4.2.3.121 soluble
-
 Salvia officinalis
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.116 Mg2+ or Mn2+, required. Mg2+ is preferred over Mn2+ Salvia officinalis
4.2.3.116 Mn2+ or Mn2+, required. Mg2+ is preferred over Mn2+, Mn2+ shows 60-70% of the activity with Mg2+ Salvia officinalis
4.2.3.117 Mg2+ or Mn2+, required. Mg2+ is preferred over Mn2+ Salvia officinalis
4.2.3.117 Mn2+ or Mn2+, required. Mg2+ is preferred over Mn2+, Mn2+ shows 60-70% of the activity with Mg2+ Salvia officinalis
4.2.3.119 Mg2+ or Mn2+, required. Mg2+ is preferred over Mn2+ Salvia officinalis
4.2.3.119 Mn2+ or Mn2+, required. Mg2+ is preferred over Mn2+, Mn2+ shows 60-70% of the activity with Mg2+ Salvia officinalis
4.2.3.120 Mg2+ or Mn2+, required. Mg2+ is preferred over Mn2+ Salvia officinalis
4.2.3.120 Mn2+ or Mn2+, required. Mg2+ is preferred over Mn2+, Mn2+ shows 60-70% of the activity with Mg2+ Salvia officinalis
4.2.3.121 Mg2+ or Mn2+, required. Mg2+ is preferred over Mn2+ Salvia officinalis
4.2.3.121 Mn2+ or Mn2+, required. Mg2+ is preferred over Mn2+, Mn2+ shows 60-70% of the activity with Mg2+ Salvia officinalis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.3.116 95000
-
 gel filtration Salvia officinalis
4.2.3.117 95000
-
 gel filtration Salvia officinalis
4.2.3.119 95000
-
 gel filtration Salvia officinalis
4.2.3.120 95000
-
 gel filtration Salvia officinalis
4.2.3.121 95000
-
 gel filtration Salvia officinalis

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.116 Salvia officinalis
-
-
-
4.2.3.117 Salvia officinalis
-
-
-
4.2.3.119 Salvia officinalis
-
-
-
4.2.3.120 Salvia officinalis
-
-
-
4.2.3.121 Salvia officinalis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.3.116 leaf immature leaf Salvia officinalis
-
4.2.3.117 leaf immature leaf Salvia officinalis
-
4.2.3.119 leaf immature leaf Salvia officinalis
-
4.2.3.120 leaf immature leaf Salvia officinalis
-
4.2.3.121 leaf immature leaf Salvia officinalis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.116 geranyl diphosphate
-
 Salvia officinalis (+)-camphene + diphosphate products are (+)-camphene, (+)-alpha-pinene and (+)-limonene ?
4.2.3.117 geranyl diphosphate
-
 Salvia officinalis (-)-camphene + diphosphate products are (-)-camphene, (-)-alpha-pinene, (-)-beta-pinene, (-)-limonene and myrcene ?
4.2.3.117 additional information each product exhibits the same absolute configuration at the center derived from C-6 of geranyl diphosphate, i e. the isopropylidene-substituted carbon Salvia officinalis ?
-
 ?
4.2.3.119 geranyl diphosphate
-
 Salvia officinalis (-)-alpha-pinene + diphosphate products are (-)-camphene, (-)-alpha-pinene, (-)-beta-pinene, (-)-limonene and myrcene ?
4.2.3.119 additional information each product exhibits the same absolute configuration at the center derived from C-6 of geranyl diphosphate, i e. the isopropylidene-substituted carbon Salvia officinalis ?
-
 ?
4.2.3.120 geranyl diphosphate
-
 Salvia officinalis (-)-beta-pinene + diphosphate products are (-)-camphene, (-)-alpha-pinene, (-)-beta-pinene, (-)-limonene and myrcene ?
4.2.3.120 additional information each product exhibits the same absolute configuration at the center derived from C-6 of geranyl diphosphate, i e. the isopropylidene-substituted carbon Salvia officinalis ?
-
 ?
4.2.3.121 geranyl diphosphate
-
 Salvia officinalis (+)-alpha-pinene + diphosphate products are (+)-camphene, (+)-alpha-pinene and (+)-limonene ?
4.2.3.121 additional information each product exhibits the same absolute configuration at the center derived from C-6 of geranyl diphosphate, i e. the isopropylidene-substituted carbon Salvia officinalis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.116 cyclase I
-
 Salvia officinalis
4.2.3.117 cyclase II
-
 Salvia officinalis
4.2.3.119 cyclase II
-
 Salvia officinalis
4.2.3.120 cyclase II
-
 Salvia officinalis
4.2.3.121 cyclase I
-
 Salvia officinalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.3.116 6
-
-
 Salvia officinalis
4.2.3.117 6
-
-
 Salvia officinalis
4.2.3.119 6
-
-
 Salvia officinalis
4.2.3.120 6
-
-
 Salvia officinalis
4.2.3.121 6
-
-
 Salvia officinalis

pI Value

EC Number Organism Comment pI Value Maximum pI Value
4.2.3.116 Salvia officinalis or below, isoelectric focusing
-
 4.5
4.2.3.117 Salvia officinalis or below, isoelectric focusing
-
 4.5
4.2.3.119 Salvia officinalis or below, isoelectric focusing
-
 4.5
4.2.3.120 Salvia officinalis or below, isoelectric focusing
-
 4.5
4.2.3.121 Salvia officinalis or below, isoelectric focusing
-
 4.5