Literature summary extracted from

Shi, L.; Ermis, R.; Garcia, A.; Telgenhoff, D.; Aust, D.
Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration (2010), Int. Wound J., 7, 87-95.

Application

EC Number	Application	Comment	Organism
3.4.24.3	medicine	Clostridium histolyticum collagenase can effectively digest collagen isoforms that are present in necrotic wound tissues. Collagenase treatment enhances cell migration mediated by collagenase itself and by collagen degradation products	Hathewaya histolytica

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.3	Hathewaya histolytica	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.3	Collagen type I + H2O	-	Hathewaya histolytica	?	Clostridium collagenase itself and the degradation products of type I and III collagens lead toan increase in keratinocyte and fibroblast migration	?
3.4.24.3	Collagen type III + H2O	-	Hathewaya histolytica	?	Clostridium collagenase itself and the degradation products of type I and III collagens lead toan increase in keratinocyte and fibroblast migration	?
3.4.24.3	collagen type IV + H2O	-	Hathewaya histolytica	?	degradation products of collagen type IV induce fibroblast migration	?
3.4.24.3	collagen type V + H2O	-	Hathewaya histolytica	?	-	?
3.4.24.3	additional information	no substrate: collagen type VI	Hathewaya histolytica	?	-	?

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Release 2023.1 (January 2023)