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Literature summary extracted from

  • Dolphin, C.; Riley, J.; Smith L, R.; Shephard, E.; Phillips, I.
    Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA (1997), Genomics, 46, 260-267.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.148 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.148 N,N,N-trimethylamine + NADPH + H+ + O2 Homo sapiens
-
 N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.148 Homo sapiens P31513
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.148 liver FMO3 is the major form of flavin-containing monooxygenase expressed in adult human liver Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.148 N,N,N-trimethylamine + NADPH + H+ + O2
-
 Homo sapiens N,N,N-trimethylamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.148 EC 1.14.13.8 assigned to Homo sapiens
1.14.13.148 flavin-containing monooxygenase 3
-
 Homo sapiens
1.14.13.148 FMO3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.148 FAD
-
 Homo sapiens
1.14.13.148 NADPH dependent on Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.13.148 malfunction trimethylaminuria (fish-odor syndrome) is associated with defective hepatic N-oxidation of dietary-derived trimethylamine catalyzed by flavin-containing monooxygenase Homo sapiens