Any feedback?
Literature summary extracted from
- The FAD-containing monooxygenase-catalyzed N-oxidation and demethylation of trimethylamine in rat liver microsomes (1991), Drug Metabol. Drug Interact., 9, 201-208.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.148 | additional information | enzyme reactions are not inhibited by gas phase containing up to 80% carbon monoxide/20% oxygen mixture | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.13.148 | microsome | - |
Rattus norvegicus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.148 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.148 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.148 | N,N,N-trimethylamine + NADPH + H+ + O2 | - |
Rattus norvegicus | N,N,N-trimethylamine N-oxide + NADP+ + H2O | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.148 | FAD-containing monooxygenase | - |
Rattus norvegicus |
| 1.14.13.148 | FMO | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.148 | FAD | - |
Rattus norvegicus | |
| 1.14.13.148 | NADPH | required for activity, in the absence of NADP or NADPH, the FAD-containing monooxygenase is irreversibly inactivated at 37°C during 30 min | Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
