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Literature summary extracted from

  • Savalas, L.R.; Gasnier, B.; Damme, M.; Luebke, T.; Wrocklage, C.; Debacker, C.; Jezegou, A.; Reinheckel, T.; Hasilik, A.; Saftig, P.; Schroeder, B.
    Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L (2011), Biochem. J., 439, 113-128.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 CA-074Me
-
 Mus musculus
3.4.22.15 E-64
-
 Mus musculus
3.4.22.15 leupeptin
-
 Mus musculus
3.4.22.15 Z-Phe-Tyr-CHO specifically inhibits cathepsin L Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.15 lysosome
-
 Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.15 Disrupted in renal carcinoma 2 + H2O Mus musculus the substrate is proteolytically processed into a N-glycosylated N-terminal and a non-glycosylated C-terminal fragment, respectively. The cleavage site is between amino acid residues 214 and 261 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.15 MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 Disrupted in renal carcinoma 2 + H2O the substrate is proteolytically processed into a N-glycosylated N-terminal and a non-glycosylated C-terminal fragment, respectively. The cleavage site is between amino acid residues 214 and 261 Mus musculus ?
-
 ?