EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.2.2 | expressed in Pichia pastoris | Homo sapiens |
3.4.19.14 | expressed in Pichia pastoris | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.2 | serine-borate | competitive inhibitor which is 8fold more potent in inhibiting isoform GGT1 than in inhibiting isoform GGT5; competitive inhibitor which is 8fold more potent in inhibiting isoform GGT1 than in inhibiting isoform GGT5 | Homo sapiens | |
3.4.19.13 | serine borate | competitive, 8fold less effective as an inhibitor of isoform GGT5 than of GGT1; competitive, 8fold less effective as an inhibitor of isoform GGT5 than of GGT1 | Homo sapiens | |
3.4.19.14 | serine-borate | 8fold more potent in inhibiting GGT1 than in inhibiting GGT5 | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.2.2 | 0.008 | - |
GSSG | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0099 | - |
S-Methylglutathione | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0102 | - |
leukotriene C4 | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0105 | - |
GSH | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0106 | - |
GSH | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0108 | - |
leukotriene C4 | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0131 | - |
S-(4-nitro-benzyl)glutathione | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0148 | - |
S-(4-nitro-benzyl)glutathione | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0182 | - |
S-Methylglutathione | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0334 | - |
5-L-glutamyl-L-leucine | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0346 | - |
glutathione sulfonic acid | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0426 | - |
GSSG | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 0.0751 | - |
glutathionesulfonic acid | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
3.4.19.13 | 0.0088 | - |
oxidized glutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0102 | - |
leukotriene C4 | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0105 | - |
reduced glutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0106 | - |
reduced glutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0108 | - |
leukotriene C4 | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0131 | - |
S-(4-nitro-benzyl)glutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0148 | - |
S-(4-nitro-benzyl)glutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0182 | - |
S-Methylglutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0334 | - |
gamma-glutamyl L-leucine | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0346 | - |
glutathione sulfonic acid | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0426 | - |
oxidized glutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.0751 | - |
glutathione sulfonic acid | pH 7.4, 37°C | Homo sapiens | |
3.4.19.13 | 0.099 | - |
S-Methylglutathione | pH 7.4, 37°C | Homo sapiens | |
3.4.19.14 | 0.0102 | - |
leukotriene C4 | in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
3.4.19.14 | 0.0148 | - |
S-(4-nitro-benzyl)glutathione | in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
3.4.19.14 | 0.0182 | - |
S-Methylglutathione | in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
3.4.19.14 | 0.0751 | - |
glutathione sulfonic acid | in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
3.4.19.14 | 0.105 | - |
reduced glutathione | in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
3.4.19.14 | 0.426 | - |
oxidized glutathione | in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.2.2 | 22000 | - |
1 * 64000 + 1 * 22000, isoform GGT1, SDS-PAGE | Homo sapiens |
2.3.2.2 | 25000 | - |
1 * 64000 + 1 * 25000, isoform GGT5, SDS-PAGE | Homo sapiens |
2.3.2.2 | 64000 | - |
1 * 64000 + 1 * 22000, isoform GGT1, SDS-PAGE | Homo sapiens |
2.3.2.2 | 64000 | - |
1 * 64000 + 1 * 25000, isoform GGT5, SDS-PAGE | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.2.2 | Homo sapiens | - |
- |
- |
2.3.2.2 | Homo sapiens | P19440 | isoform GGT1 | - |
3.4.19.13 | Homo sapiens | P19440 | - |
- |
3.4.19.13 | Homo sapiens | P36269 | - |
- |
3.4.19.14 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.2.2 | - |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.2.2 | 5-L-glutamyl-4-nitroanilide + glycylglycine | substrate for isoform GGT1 | Homo sapiens | 5-L-glutamyl-glycylglycine + 4-nitroaniline | - |
? | |
2.3.2.2 | 5-L-glutamyl-L-leucine + glycylglycine | - |
Homo sapiens | L-Leu + 5-L-glutamyl-glycylglycine | - |
? | |
2.3.2.2 | glutathione sulfonic acid + glycylglycine | - |
Homo sapiens | ? | - |
? | |
2.3.2.2 | glutathionesulfonic acid + glycylglycine | - |
Homo sapiens | ? | - |
? | |
2.3.2.2 | GSH + glycylglycine | - |
Homo sapiens | L-Cys-Gly + 5-L-glutamyl-glycylglycine | - |
? | |
2.3.2.2 | GSSG + glycylglycine | - |
Homo sapiens | L-Cys-Gly + 5-L-glutamyl-glycylglycine | - |
? | |
2.3.2.2 | leukotriene C4 + glycylglycine | - |
Homo sapiens | leukotriene D4 + 5-L-glutamyl-glycylglycine | - |
? | |
2.3.2.2 | additional information | isoform GGT5 does not cleave 5-L-glutamyl-4-nitroanilide and gamma-glutamyl leucine | Homo sapiens | ? | - |
? | |
2.3.2.2 | S-(4-nitro-benzyl)glutathione + glycylglycine | - |
Homo sapiens | ? | - |
? | |
2.3.2.2 | S-methylglutathione + glycylglycine | - |
Homo sapiens | ? | - |
? | |
3.4.19.13 | gamma-glutamyl L-leucine + H2O | - |
Homo sapiens | L-leucine + L-glutamate | - |
? | |
3.4.19.13 | glutathione sulfonic acid + H2O | - |
Homo sapiens | ? + L-glutamate | - |
? | |
3.4.19.13 | leukotriene C4 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.19.13 | additional information | no substrate: gamma-glutamyl L-leucine | Homo sapiens | ? | - |
? | |
3.4.19.13 | additional information | protein additionally has EC 2.3.2.2, gamma-glutamyltransferase activity | Homo sapiens | ? | - |
? | |
3.4.19.13 | oxidized glutathione + H2O | - |
Homo sapiens | ? + L-glutamate | - |
? | |
3.4.19.13 | reduced glutathione + H2O | - |
Homo sapiens | L-cysteinylglycine + L-glutamate | - |
? | |
3.4.19.13 | S-(4-nitro-benzyl)glutathione + H2O | - |
Homo sapiens | S-(4-nitro-benzyl)-L-cysteinylglycine + L-glutamate | - |
? | |
3.4.19.13 | S-methylglutathione + H2O | - |
Homo sapiens | S-methyl-L-cysteinylglycine + L-glutamate | - |
? | |
3.4.19.14 | glutathione sulfonic acid + H2O + glycylglycine | - |
Homo sapiens | ? + gamma-glutamyl-glycylglycine | - |
? | |
3.4.19.14 | leukotriene C4 + H2O | - |
Homo sapiens | leukotriene D4 + L-glutamate | - |
? | |
3.4.19.14 | additional information | no activity with gamma-glutamyl leucine | Homo sapiens | ? | - |
? | |
3.4.19.14 | oxidized glutathione + H2O + glycylglycine | - |
Homo sapiens | ? + gamma-glutamyl-glycylglycine | - |
? | |
3.4.19.14 | reduced glutathione + H2O + glycylglycine | - |
Homo sapiens | ? + gamma-glutamyl-glycylglycine | - |
? | |
3.4.19.14 | S-(4-nitro-benzyl)glutathione + H2O + glycylglycine | - |
Homo sapiens | ? + gamma-glutamyl-glycylglycine | - |
? | |
3.4.19.14 | S-methylglutathione + H2O + glycylglycine | - |
Homo sapiens | ? + gamma-glutamyl-glycylglycine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.2.2 | heterodimer | 1 * 64000 + 1 * 22000, isoform GGT1, SDS-PAGE | Homo sapiens |
2.3.2.2 | heterodimer | 1 * 64000 + 1 * 25000, isoform GGT5, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.2.2 | gamma-glutamyl transpeptidase | - |
Homo sapiens |
2.3.2.2 | GGT1 | isoform | Homo sapiens |
2.3.2.2 | GGT5 | isoform | Homo sapiens |
3.4.19.13 | gamma-glutamyl transpeptidase | - |
Homo sapiens |
3.4.19.13 | GGT1 | - |
Homo sapiens |
3.4.19.13 | GGT5 | - |
Homo sapiens |
3.4.19.14 | gamma-glutamyl leukotrienase | - |
Homo sapiens |
3.4.19.14 | GGT5 | isoform B | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.2.2 | 4.2 | - |
serine-borate | isoform GGT5, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
2.3.2.2 | 41.6 | - |
serine-borate | isoform GGT1, in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C | Homo sapiens | |
3.4.19.13 | 4.2 | - |
serine borate | pH 7.4, 37°C | Homo sapiens |