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Literature summary extracted from

  • Lin, M.C.; Yeh, S.J.; Chen, I.R.; Lin, G.
    Stereoselective inhibition of cholesterol esterase by enantiomers of exo- and endo-2-norbornyl-N-n-butylcarbamates (2011), Protein J., 30, 220-227.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 (R)-endo-2-norbornyl-N-n-butyl-carbamate
-
 Sus scrofa
3.1.1.13 (R)-exo-2-norbornyl-N-n-butylcarbamate the R-enantiomer is 6.8times more potent than the S-enantiomer Sus scrofa
3.1.1.13 (S)-endo-2-norbornyl-N-n-butyl-carbamate the S-enantiomer is 4.6times more potent than the R-enantiomer Sus scrofa
3.1.1.13 (S)-exo-2-norbornyl-N-n-butylcarbamate
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 4-nitrophenyl butyrate + H2O
-
 Sus scrofa 4-nitrophenol + butyrate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 bile salt-activated lipase
-
 Sus scrofa
3.1.1.13 Carboxyl ester lipase
-
 Sus scrofa
3.1.1.13 CEase
-
 Sus scrofa
3.1.1.13 cholesterol esterase
-
 Sus scrofa
3.1.1.13 lysophospholipase
-
 Sus scrofa
3.1.1.13 non-specific lipase
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.13 0.0004
-
 (R)-exo-2-norbornyl-N-n-butylcarbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa
3.1.1.13 0.0013
-
 (S)-endo-2-norbornyl-N-n-butyl-carbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa
3.1.1.13 0.0025
-
 (S)-exo-2-norbornyl-N-n-butylcarbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa
3.1.1.13 0.009
-
 (R)-endo-2-norbornyl-N-n-butyl-carbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa