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Literature summary extracted from

  • Redmond, T.M.; Poliakov, E.; Yu, S.; Tsai, J.Y.; Lu, Z.; Gentleman, S.
    Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle (2005), Proc. Natl. Acad. Sci. USA, 102, 13658-13663.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.64 expressed in 293-F cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.64 A132T 50% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 A434V 55% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 C231S 55% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 C329S 26% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 C329S/C330S less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 C330T 83% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 C330Y less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 E417A less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 E417Q less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 G40S less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 G528V less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H180A less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H182A 10% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H182Y 10% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H241A less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H313A less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H527A less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H68A less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 H68Y less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 K294T 16% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 R44Q less than 2% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 Y368F 56% activity compared to the wild type enzyme Homo sapiens
3.1.1.64 Y368H less than 3% activity compared to the wild type enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.64 2,2'-dipyridyl
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.64 61000
-
 x * 61000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.64 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.64 retinal pigment epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.64 all-trans-retinyl ester + H2O
-
 Homo sapiens 11-cis-retinol + a fatty acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.64 ? x * 61000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.64 Rpe65
-
 Homo sapiens