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Literature summary extracted from

  • Maloberti, P.M.; Duarte, A.B.; Orlando, U.D.; Pasqualini, M.E.; Solano, A.R.; Lopez-Otin, C.; Podesta, E.J.
    Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells (2010), PLoS ONE, 5, e15540.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.15 overexpression of ACSL4 in the MCF-7 Tet-off/ACSL4 cell line affects cell proliferation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
6.2.1.15 additional information a model of ACSL4 knock-down shows a very clear reduction in mRNA and protein levels that paralleles the reduction in cell growth Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.15 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.15 ATP + arachidonate + CoA Homo sapiens
-
 AMP + diphosphate + arachidonoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.15 breast cancer cell a breast cancer cell model, comprising different cell lines, expresses ACSL4 in all cell lines, high expression level Homo sapiens
-
6.2.1.15 MCF-7 cell
-
 Homo sapiens
-
6.2.1.15 MDA-MB-231 cell
-
 Homo sapiens
-
6.2.1.15 additional information ACSL4 is abundant in steroidogenic tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.15 ATP + arachidonate + CoA
-
 Homo sapiens AMP + diphosphate + arachidonoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.15 ACSL4
-
 Homo sapiens
6.2.1.15 Acyl-CoA synthetase
-
 Homo sapiens
6.2.1.15 FACL4
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.15 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.2.1.15 metabolism The alternative pathway, in which the rate-limiting enzyme is ACSL4, provides arachidonoyl-CoA to a mitochondrial acyl-CoA thioesterase that releases AA in mitochondria and directs this fatty acid to the lipooxygenase for its subsequent conversion to lipooxygenase metabolites Homo sapiens
6.2.1.15 physiological function the acyl-CoA synthetase, ACSL4, belongs to a five member family of enzymes that esterify mainly arachidonic acid into acyl-CoA. Role of ACSL4 and acyl-CoA thioesterase, ACOT2, in the production of lipooxygenase metabolites in breast cancer cells, regulation, overview. ACSL4 is the rate-limiting enzyme for intramitochondrial arachidonic acid generation and export, for the conversion to lipooxygenase metabolites Homo sapiens