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Literature summary extracted from

  • Zhao, W.; Cheng, X.; Huang, Z.; Fan, H.; Wu, H., Ling, H.Q.
    Tomato LeTHIC is an Fe-requiring HMP-P synthase involved in thiamine synthesis and regulated by multiple factors (2011), Plant Cell Physiol., 52, 967-982.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.99.17 LeThiC under the control of the cauliflower mosaic virus 35S promoter is introduced into the tl mutant by Agrobacterium tumefaciens-mediated transformation. Expression of the wild-type LeThiC gene in the tl mutant is able to complement the mutant to wild type Solanum lycopersicum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.99.17 chloroplast
-
 Solanum lycopersicum 9507
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.99.17 iron-sulfur centre
-
 Solanum lycopersicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine Solanum lycopersicum the enzyme is involved in thiamin biosynthesis 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.17 Solanum lycopersicum B9TU32
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.99.17 leaf
-
 Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine
-
 Solanum lycopersicum 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine the enzyme is involved in thiamin biosynthesis Solanum lycopersicum 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.99.17 LeThiC
-
 Solanum lycopersicum

Expression

EC Number Organism Comment Expression
4.1.99.17 Solanum lycopersicum expression of LeThiC is tightly regulated at the transcriptional and posttranscriptional level by multiple factors, such as light, Fe2+ status and thiamine diphosphate-riboswitch. A feedback regulation mechanism is involved in synthesis of the pyrimidine moiety for controlling thiamine synthesis in tomato additional information
4.1.99.17 Solanum lycopersicum the abundance of LeTHIC expression is dependent on light up
4.1.99.17 Solanum lycopersicum the expression intensity of LeThic at both the transcriptional (S form mRNA) and protein levels is increased under Fe2+ deficiency (1 or 0 mM Fe2+) compared with Fe2+ sufficiency (10 and 100 mM Fe2+), whereas no effects on LeThiC expression are observed under deficiency of Zn2+ or Mn2+ up

General Information

EC Number General Information Comment Organism
4.1.99.17 physiological function the enzyme is involved in thiamine biosynthesis Solanum lycopersicum