Literature summary extracted from

Redmond, T.M.; Yu, S.; Lee, E.; Bok, D.; Hamasaki, D.; Chen, N.; Goletz, P.; Ma, J.X.; Crouch, R.K.; Pfeifer, K.
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle (1998), Nat. Genet., 20, 344-351.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.64	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.1.64	retinal pigment epithelium	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.64	all-trans-retinyl ester + H2O	-	Mus musculus	11-cis-retinol + a fatty acid	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.1.64	Rpe65	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
3.1.1.64	malfunction	outer segment discs of rod photoreceptors in Rpe65-deficient mice are disorganized, rod function is abolished although cone function remains. Rpe65-deficient mice lack rhodopsin, but not opsin apoprotein	Mus musculus
3.1.1.64	physiological function	Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)