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Literature summary extracted from

  • Vigueira, P.A.; Paul, K.S.
    Requirement for acetyl-CoA carboxylase in Trypanosoma brucei is dependent upon the growth environment (2011), Mol. Microbiol., 80, 117-132.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 cytoplasm
-
 Trypanosoma brucei 5737
-

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Trypanosoma brucei ADP + malonyl-CoA + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.2 ? x * about 200000, SDS-PAGE Trypanosoma brucei
6.4.1.2 ? x * about 243000, estimated from amino acid sequence Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
6.4.1.2 ACC
-
 Trypanosoma brucei

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 ATP
-
 Trypanosoma brucei
6.4.1.2 biotin
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
6.4.1.2 malfunction in procyclic forms, ACC RNAi results in 50-75% reduction in fatty acid elongation and a 64% reduction in growth in low-lipid media. In bloodstream forms, ACC RNAi results in a minor 15% decrease in fatty acid elongation and no growth defect in culture, even in low-lipid media. ACC RNAi does attenuate virulence in a mouse model of infection Trypanosoma brucei
6.4.1.2 metabolism ACC is required for elongation of fatty acids, both laurate and myristate are elongated to products up to 18 carbons Trypanosoma brucei
6.4.1.2 physiological function ACC is required by procyclic forms for growth in culture under lipid-limited conditions and by bloodstream forms for full virulence in mice Trypanosoma brucei