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Literature summary extracted from

  • Heym, B.; Alzari, P.M.; Honore, N.; Cole, S.T.
    Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis (1995), Mol. Microbiol., 15, 235-245.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.11.1.21 medicine the toxicity of the anti-tuberculosis drug isoniazid is mediated by catalase-peroxidase Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.21 L587M the mutant has wild type-like strong catalase and peroxidase activities Mycobacterium tuberculosis
1.11.1.21 R463L the mutant has wild type-like strong catalase and peroxidase activities Mycobacterium tuberculosis
1.11.1.21 S315T the mutant has weak catalase and barely detectable peroxidase activities Mycobacterium tuberculosis
1.11.1.21 T275P the mutant has very low catalase activity Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.21 Mycobacterium tuberculosis
-
-
-
1.11.1.21 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.21 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
1.11.1.21 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
1.11.1.21 H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
1.11.1.21 H2O2
-
 Mycobacterium tuberculosis H37Rv O2 + H2O
-
 ?
1.11.1.21 o-dianisidine + H2O2
-
 Mycobacterium tuberculosis oxidized o-dianisidine + H2O
-
 ?
1.11.1.21 o-dianisidine + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized o-dianisidine + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.21 KatG
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.21 heme
-
 Mycobacterium tuberculosis