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Literature summary extracted from

  • Penmatsa, H.; Zhang, W.; Yarlagadda, S.; Li, C.; Conoley, V.G.; Yue, J.; Bahouth, S.W.; Buddington, R.K.; Zhang, G.; Nelson, D.J.; Sonecha, M.D.; Manganiello, V.; Wine, J.J.; Naren, A.P.
    Compartmentalized cyclic adenosine 3',5'-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains (2010), Mol. Biol. Cell, 21, 1097-1110.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.17 PDE3A expression in HEK-293 cells on the plasma membrane Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 adenosine
-
 Homo sapiens
3.1.4.17 adenosine
-
 Sus scrofa
3.1.4.17 cilostazol a PDE3 inhibitor Homo sapiens
3.1.4.17 cilostazol a PDE3 inhibitor Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.17 plasma membrane
-
 Homo sapiens 5886
-
3.1.4.17 plasma membrane
-
 Sus scrofa 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.17 additional information Homo sapiens PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel ?
-
 ?
3.1.4.17 additional information Sus scrofa PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens
-
-
-
3.1.4.17 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 Calu-3 cell
-
 Homo sapiens
-
3.1.4.17 epithelial cell
-
 Homo sapiens
-
3.1.4.17 epithelial cell
-
 Sus scrofa
-
3.1.4.17 lung trachea submucosal gland Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 additional information PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel Homo sapiens ?
-
 ?
3.1.4.17 additional information PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 PDE3A
-
 Homo sapiens
3.1.4.17 PDE3A
-
 Sus scrofa
3.1.4.17 phosphodiesterase type 3A
-
 Homo sapiens
3.1.4.17 phosphodiesterase type 3A
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
3.1.4.17 physiological function PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel. PDE3A inhibition generates compartmentalized cAMP, which further clusters PDE3A and CFTR into microdomains at the plasma membrane and potentiates CFTR channel function. Actin skeleton disruption reduces PDE3A-CFTR interaction and segregates PDE3A from its interacting partners, thus compromising the integrity of the CFTR-PDE3A-containing macromolecular complex, compartmentalized cAMP signaling is lost Homo sapiens
3.1.4.17 physiological function PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel. PDE3A inhibition generates compartmentalized cAMP, which further clusters PDE3A and CFTR into microdomains at the plasma membrane and potentiates CFTR channel function. Actin skeleton disruption reduces PDE3A-CFTR interaction and segregates PDE3A from its interacting partners, thus compromising the integrity of the CFTR-PDE3A-containing macromolecular complex, compartmentalized cAMP signaling is lost Sus scrofa