EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.14.19 | A105L | site-directed mutagenesis, the single point mutation is sufficient to strongly reduce the 16-hydroxylase activity of the enzyme | Homo sapiens |
1.14.14.19 | L105A | site-directed mutagenesis, the single point mutation is sufficient to confer 16-hydroxylase activity to the enzyme. It also reduced the rate of progesterone conversion | Papio ursinus |
1.14.14.19 | L105A | site-directed mutagenesis, the single point mutation is sufficient to confer 16-hydroxylase activity to the enzyme. It also reduced the rate of progesterone conversion | Sus scrofa |
1.14.14.19 | L105A | site-directed mutagenesis, the single point mutation is sufficient to confer 16-hydroxylase activity to the enzyme. It also reduced the rate of progesterone conversion | Capra hircus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.19 | Capra hircus | A5HEW0 | - |
- |
1.14.14.19 | Capra hircus South African angora | A5HEW0 | - |
- |
1.14.14.19 | Homo sapiens | P05093 | - |
- |
1.14.14.19 | Papio ursinus | Q9GLD2 | - |
- |
1.14.14.19 | Sus scrofa | P19100 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.19 | cytochrome P450 17alpha-hydroxylase/17,20 lyase | - |
Homo sapiens |
1.14.14.19 | cytochrome P450 17alpha-hydroxylase/17,20 lyase | - |
Papio ursinus |
1.14.14.19 | cytochrome P450 17alpha-hydroxylase/17,20 lyase | - |
Sus scrofa |
1.14.14.19 | cytochrome P450 17alpha-hydroxylase/17,20 lyase | - |
Capra hircus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.14.19 | additional information | CYP17 also exhibits 16alpha-hydroxylase activity towards progesterone in some species, with only human and chimp CYP17 catalysing the biosynthesis of substantial amounts of 16-hydroxy-progesterone. Residue 105 is responsible for the activity, homology modelling, overview | Homo sapiens |
1.14.14.19 | additional information | CYP17 also exhibits 16alpha-hydroxylase activity towards progesterone in some species, with only human and chimp CYP17 catalysing the biosynthesis of substantial amounts of 16-hydroxy-progesterone. Residue 105 is responsible for the activity, homology modelling, overview | Papio ursinus |
1.14.14.19 | additional information | CYP17 also exhibits 16alpha-hydroxylase activity towards progesterone in some species, with only human and chimp CYP17 catalysing the biosynthesis of substantial amounts of 16-hydroxy-progesterone. Residue 105 is responsible for the activity, homology modelling, overview | Sus scrofa |
1.14.14.19 | additional information | CYP17 also exhibits 16alpha-hydroxylase activity towards progesterone in some species, with only human and chimp CYP17 catalysing the biosynthesis of substantial amounts of 16-hydroxy-progesterone. Residue 105 is responsible for the activity, homology modelling, overview | Capra hircus |