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Literature summary extracted from

  • Shrestha, S.; Kim, Y.
    Biochemical characteristics of immune-associated phospholipase A2 and its inhibition by an entomopathogenic bacterium, Xenorhabdus nematophila (2010), J. Microbiol., 47, 774-782.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.4 expressed in Escherichia coli Top10 cells Tribolium castaneum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 bromophenacyl bromide specific sPLA2 inhibitor Tribolium castaneum
3.1.1.4 dithiothreitol
-
 Tribolium castaneum
3.1.1.4 EGTA almost complete inhibition at 0.06 mM EGTA Tribolium castaneum
3.1.1.4 additional information sPLA2 is not inhibited by methylarachidonyl fluorophosphonate Tribolium castaneum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.4 Ca2+ stimulation of activity in the presence of 0.6 mM Ca2+ Tribolium castaneum

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Tribolium castaneum C0LTQ2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycerol-3-phosphatidyl choline + H2O
-
 Tribolium castaneum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 secretory phospholipase A2
-
 Tribolium castaneum
3.1.1.4 sPLA2
-
 Tribolium castaneum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.4 30
-
-
 Tribolium castaneum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.4 8
-
-
 Tribolium castaneum

Expression

EC Number Organism Comment Expression
3.1.1.4 Tribolium castaneum Xenorhabdus nematophila induces an immunosuppression of target insects by inhibiting phospholipase A2 activity down