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Literature summary extracted from

  • Stefanachi, A.; Favia, A.; Nicolotti, O.; Leonetti, F.; Pisani, L.; Catto, M.; Zimmer, C.; Hartmann, R.; Carotti, A.
    Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-alpha-hydroxylase/C17-20 lyase (2011), J. Med. Chem., 54, 1613-1625.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.19 recombinant expression in Escherichia coli Homo sapiens
1.14.14.32 recombinant expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 2-fluoro-4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]phenol
-
Homo sapiens
1.14.14.19 2-fluoro-4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]phenol
-
Homo sapiens
1.14.14.19 3-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine
-
Homo sapiens
1.14.14.19 3-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine
-
Homo sapiens
1.14.14.19 4-(1H-imidazol-1-ylmethyl)-7-[(3-methylbenzyl)oxy]-2H-chromen-2-one
-
Homo sapiens
1.14.14.19 4-(1H-imidazol-1-ylmethyl)-7-[[3-(trifluoromethyl)benzyl]oxy]-2Hchromen-2-one
-
Homo sapiens
1.14.14.19 4-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine
-
Homo sapiens
1.14.14.19 4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]benzene-1,2-diol
-
Homo sapiens
1.14.14.19 4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]benzene-1,2-diol
-
Homo sapiens
1.14.14.19 4-[6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.19 4-[6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.19 4-[6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.19 4-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine
-
Homo sapiens
1.14.14.19 4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.19 4-[6-(4-methoxyphenyl)-1H-inden-3-yl]pyridine
-
Homo sapiens
1.14.14.19 5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol
-
Homo sapiens
1.14.14.19 6-(3,4-difluorophenyl)-1-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
Homo sapiens
1.14.14.19 6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
Homo sapiens
1.14.14.19 7-[(3-chlorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one
-
Homo sapiens
1.14.14.19 7-[(3-fluorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one
-
Homo sapiens
1.14.14.32 2-fluoro-4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]phenol
-
Homo sapiens
1.14.14.32 2-fluoro-4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]phenol
-
Homo sapiens
1.14.14.32 3-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine
-
Homo sapiens
1.14.14.32 3-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine
-
Homo sapiens
1.14.14.32 4-(1H-imidazol-1-ylmethyl)-7-[(3-methylbenzyl)oxy]-2H-chromen-2-one
-
Homo sapiens
1.14.14.32 4-(1H-imidazol-1-ylmethyl)-7-[[3-(trifluoromethyl)benzyl]oxy]-2Hchromen-2-one
-
Homo sapiens
1.14.14.32 4-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine
-
Homo sapiens
1.14.14.32 4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]benzene-1,2-diol
-
Homo sapiens
1.14.14.32 4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]benzene-1,2-diol
-
Homo sapiens
1.14.14.32 4-[6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.32 4-[6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.32 4-[6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.32 4-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine
-
Homo sapiens
1.14.14.32 4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
-
Homo sapiens
1.14.14.32 4-[6-(4-methoxyphenyl)-1H-inden-3-yl]pyridine
-
Homo sapiens
1.14.14.32 5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol
-
Homo sapiens
1.14.14.32 6-(3,4-difluorophenyl)-1-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
Homo sapiens
1.14.14.32 6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
Homo sapiens
1.14.14.32 7-[(3-chlorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one
-
Homo sapiens
1.14.14.32 7-[(3-fluorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 progesterone + reduced acceptor + O2 Homo sapiens
-
17alpha-hydroxyprogesterone + acceptor + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-
1.14.14.32 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 progesterone + reduced acceptor + O2
-
Homo sapiens 17alpha-hydroxyprogesterone + acceptor + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 17-alpha-hydroxylase/C17-20 lyase
-
Homo sapiens
1.14.14.19 CYP17
-
Homo sapiens
1.14.14.32 17-alpha-hydroxylase/C17-20 lyase
-
Homo sapiens
1.14.14.32 CYP17
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.19 physiological function 17alpha-hydroxylase/C17,20-lyase, CYP17, a P450 enzyme, is responsible for catalyzing the final step in androgen biosynthesis Homo sapiens
1.14.14.32 physiological function 17alpha-hydroxylase/C17,20-lyase, CYP17, a P450 enzyme, is responsible for catalyzing the final step in androgen biosynthesis Homo sapiens