BRENDA - Enzyme Database show

Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D2 synthases

Christ, A.N.; Labzin, L.; Bourne, G.T.; Fukunishi, H.; Weber, J.E.; Sweet, M.J.; Smythe, M.L.; Flanagan, J.U.; J. Med. Chem. 53, 5536-5548 (2010)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
2-phenyl-5-(1H-pyrazol-3-yl)thiazole
-
Homo sapiens
5.3.99.2
2-phenyl-5-(1H-pyrazol-3-yl)thiazole
-
Mus musculus
5.3.99.2
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid
-
Homo sapiens
5.3.99.2
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid
-
Mus musculus
5.3.99.2
5-(3-aminophenyl)-N-benzhydrylthiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
5-(3-cyanophenyl)-N-(diphenylmethyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
5-(3-cyanophenyl)-N-(diphenylmethyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
5-(3-hydroxyphenyl)thiophene-2-carboxylic acid
-
Homo sapiens
5.3.99.2
5-(3-hydroxyphenyl)thiophene-2-carboxylic acid
-
Mus musculus
5.3.99.2
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid
-
Homo sapiens
5.3.99.2
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid
-
Mus musculus
5.3.99.2
HQL-79
-
Homo sapiens
5.3.99.2
HQL-79
-
Mus musculus
5.3.99.2
N-(1,6-diamino-1-oxohexan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1,6-diamino-1-oxohexan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-2,3'-dihydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-2,3'-dihydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-3-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-3-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(thiophen-2-yl)benzamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(thiophen-2-yl)benzamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide
selective H-PGDS inhibitor with low micromolar potency in the inhibition of the purified enzyme
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide
selective H-PGDS inhibitor with low micromolar potency in the inhibition of the purified enzyme
Mus musculus
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-methyl-1-oxobutan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-methyl-1-oxobutan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-2-phenyl-1,3-thiazole-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-2-phenyl-1,3-thiazole-4-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-5-phenylthiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-5-phenylthiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)biphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)biphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide
; low micromolar potency in the inhibition of the purified enzyme
Homo sapiens
5.3.99.2
N-[4-methyl-3-({3-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)phenyl]-3-phenyl-1,2-thiazole-5-carboxamide
-
Homo sapiens
5.3.99.2
N-[4-methyl-3-({3-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)phenyl]-3-phenyl-1,2-thiazole-5-carboxamide
-
Mus musculus
5.3.99.2
phenyl(thiophen-2-yl)methanone
-
Homo sapiens
5.3.99.2
phenyl(thiophen-2-yl)methanone
-
Mus musculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Homo sapiens
-
-
-
5.3.99.2
Mus musculus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.3.99.2
GST-Prep column chromatography
Homo sapiens
5.3.99.2
GST-Prep column chromatography
Mus musculus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
bone marrow-derived macrophage
primary cell
Mus musculus
-
5.3.99.2
MEG-01S cell
-
Homo sapiens
-
5.3.99.2
primary bone marrow-derived macrophage
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
715845
Mus musculus
Prostaglandin D2
-
-
-
?
5.3.99.2
Prostaglandin H2
-
715845
Homo sapiens
Prostaglandin D2
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.2
glutathione
required
Homo sapiens
5.3.99.2
glutathione
required
Mus musculus
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.3.99.2
0.0007
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
2-phenyl-5-(1H-pyrazol-3-yl)thiazole
5.3.99.2
0.0007
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.001
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
5.3.99.2
0.0012
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide
5.3.99.2
0.0013
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.0014
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid
5.3.99.2
0.0019
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
5-(3-aminophenyl)-N-benzhydrylthiophene-2-carboxamide
5.3.99.2
0.0021
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.0037
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
5.3.99.2
0.0038
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
HQL-79
5.3.99.2
0.0046
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
5.3.99.2
0.0071
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
5.3.99.2
0.008
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.0108
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide
5.3.99.2
0.0128
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
phenyl(thiophen-2-yl)methanone
5.3.99.2
0.023
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid
5.3.99.2
0.0248
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
5.3.99.2
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.2
glutathione
required
Homo sapiens
5.3.99.2
glutathione
required
Mus musculus
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.3.99.2
0.0007
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
2-phenyl-5-(1H-pyrazol-3-yl)thiazole
5.3.99.2
0.0007
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.001
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
5.3.99.2
0.0012
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide
5.3.99.2
0.0013
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.0014
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid
5.3.99.2
0.0019
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
5-(3-aminophenyl)-N-benzhydrylthiophene-2-carboxamide
5.3.99.2
0.0021
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.0037
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
5.3.99.2
0.0038
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
HQL-79
5.3.99.2
0.0046
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
5.3.99.2
0.0071
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
5.3.99.2
0.008
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
5.3.99.2
0.0108
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide
5.3.99.2
0.0128
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
phenyl(thiophen-2-yl)methanone
5.3.99.2
0.023
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid
5.3.99.2
0.0248
-
in 0.1 M Tris-HCl, pH 8.0, at 25°C
Homo sapiens
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
2-phenyl-5-(1H-pyrazol-3-yl)thiazole
-
Homo sapiens
5.3.99.2
2-phenyl-5-(1H-pyrazol-3-yl)thiazole
-
Mus musculus
5.3.99.2
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid
-
Homo sapiens
5.3.99.2
4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid
-
Mus musculus
5.3.99.2
5-(3-aminophenyl)-N-benzhydrylthiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
5-(3-cyanophenyl)-N-(diphenylmethyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
5-(3-cyanophenyl)-N-(diphenylmethyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
5-(3-hydroxyphenyl)thiophene-2-carboxylic acid
-
Homo sapiens
5.3.99.2
5-(3-hydroxyphenyl)thiophene-2-carboxylic acid
-
Mus musculus
5.3.99.2
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid
-
Homo sapiens
5.3.99.2
5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid
-
Mus musculus
5.3.99.2
HQL-79
-
Homo sapiens
5.3.99.2
HQL-79
-
Mus musculus
5.3.99.2
N-(1,6-diamino-1-oxohexan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1,6-diamino-1-oxohexan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-2,3'-dihydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-2,3'-dihydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-3-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-3-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(1H-indol-4-yl)benzamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(thiophen-2-yl)benzamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-4-(thiophen-2-yl)benzamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide
selective H-PGDS inhibitor with low micromolar potency in the inhibition of the purified enzyme
Homo sapiens
5.3.99.2
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide
selective H-PGDS inhibitor with low micromolar potency in the inhibition of the purified enzyme
Mus musculus
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-cyclohexyl-1-oxopropan-2-yl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-3-methyl-1-oxobutan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-3-methyl-1-oxobutan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-3'-hydroxybiphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-2-phenyl-1,3-thiazole-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-2-phenyl-1,3-thiazole-4-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-5-(1H-indol-4-yl)thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-5-phenylthiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-5-phenylthiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)-5-[3-(hydroxymethyl)phenyl]thiophene-2-carboxamide
-
Mus musculus
5.3.99.2
N-(diphenylmethyl)biphenyl-4-carboxamide
-
Homo sapiens
5.3.99.2
N-(diphenylmethyl)biphenyl-4-carboxamide
-
Mus musculus
5.3.99.2
N-benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide
; low micromolar potency in the inhibition of the purified enzyme
Homo sapiens
5.3.99.2
N-[4-methyl-3-({3-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)phenyl]-3-phenyl-1,2-thiazole-5-carboxamide
-
Homo sapiens
5.3.99.2
N-[4-methyl-3-({3-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)phenyl]-3-phenyl-1,2-thiazole-5-carboxamide
-
Mus musculus
5.3.99.2
phenyl(thiophen-2-yl)methanone
-
Homo sapiens
5.3.99.2
phenyl(thiophen-2-yl)methanone
-
Mus musculus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.2
GST-Prep column chromatography
Homo sapiens
5.3.99.2
GST-Prep column chromatography
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
bone marrow-derived macrophage
primary cell
Mus musculus
-
5.3.99.2
MEG-01S cell
-
Homo sapiens
-
5.3.99.2
primary bone marrow-derived macrophage
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
715845
Mus musculus
Prostaglandin D2
-
-
-
?
5.3.99.2
Prostaglandin H2
-
715845
Homo sapiens
Prostaglandin D2
-
-
-
?