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Literature summary extracted from

  • Bolen, A.L.; Naren, A.P.; Yarlagadda, S.; Beranova-Giorgianni, S.; Chen, L.; Norman, D.; Baker, D.L.; Rowland, M.M.; Best, M.D.; Sano, T.; Tsukahara, T.; Liliom, K.; Igarashi, Y.; Tigyi, G.
    The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation (2011), J. Lipid Res., 52, 958-970.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.32 additional information Homo sapiens monoglyceride lipase does exhibit PLA1 activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.32 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.32 native enzyme 1500fold from thrombin-activated platelets by anion exchange, hydrophobic interaction, and affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.32 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.32 additional information monoglyceride lipase does exhibit PLA1 activity Homo sapiens ?
-
 ?
3.1.1.32 phosphatidylcholine + H2O
-
 Homo sapiens lysophosphatidylcholine + fatty acid
-
 ?
3.1.1.32 phosphatidylserine + H2O
-
 Homo sapiens lysophosphatidylserine + fatty acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.32 PLA 1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.32 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.32 7.5
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.32 physiological function the phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation Homo sapiens