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Literature summary extracted from

  • Galan, M.; Miguel, M.; Beltran, A.E.; Rodriguez, C.; Garcia-Redondo, A.B.; Rodriguez-Calvo, R.; Alonso, M.J.; Martinez-Gonzalez, J.; Salaices, M.
    Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli (2011), J. Hypertens., 29, 529-536.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Rattus norvegicus
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 aortic adventitial fibroblast
-
 Rattus norvegicus
-
5.3.99.4 HAoAF cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Rattus norvegicus Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 PGI2 synthase
-
 Rattus norvegicus
5.3.99.4 PGIS
-
 Rattus norvegicus
5.3.99.4 Prostaglandin I2 synthase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.4 heme
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
5.3.99.4 Rattus norvegicus interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression additional information
5.3.99.4 Rattus norvegicus angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta up