BRENDA - Enzyme Database show

Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli

Galan, M.; Miguel, M.; Beltran, A.E.; Rodriguez, C.; Garcia-Redondo, A.B.; Rodriguez-Calvo, R.; Alonso, M.J.; Martinez-Gonzalez, J.; Salaices, M.; J. Hypertens. 29, 529-536 (2011)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aortic adventitial fibroblast
-
Rattus norvegicus
-
5.3.99.4
HAoAF cell
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
715791
Rattus norvegicus
Prostaglandin I2
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.4
heme
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.4
heme
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aortic adventitial fibroblast
-
Rattus norvegicus
-
5.3.99.4
HAoAF cell
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
715791
Rattus norvegicus
Prostaglandin I2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.4
Rattus norvegicus
interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression
additional information
5.3.99.4
Rattus norvegicus
angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta
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Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.4
Rattus norvegicus
interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression
additional information
5.3.99.4
Rattus norvegicus
angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta
up