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Literature summary extracted from

  • Martinez-Gomez, N.C.; Robers, M.; Downs, D.M.
    Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily (2004), J. Biol. Chem., 279, 40505-40510.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.1.99.19 A26G the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 A272V the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 A373P the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 A50T the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 A51V the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 A61A the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 A61T the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 C285A the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 C285H the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 C89A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 D41V the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 D6E the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 E131A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 E131K the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 E187D the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 E29K the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 E55G the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 E55K the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 G130A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 G216C the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 G22V the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 G327C the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 h124Y the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 N87A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 N87K the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 P334Q the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 P347S the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 Q338L the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 R102P the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 R205W the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 T266N the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 V257A the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 V360I the thiH mutant allele results in a phenotype with thiamine auxotrophy that is corrected by either L-tyrosine or thiazole Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 W363C the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 Y190C the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium
4.1.99.19 Y91A the thiH mutant allele results in a thiH null phenotype Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.19 Salmonella enterica subsp. enterica serovar Typhimurium Q9S498
-
-

Synonyms

EC Number Synonyms Comment Organism
4.1.99.19 thiH
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.19 iron-sulfur centre contains an oxygen labile Fe-S cluster Salmonella enterica subsp. enterica serovar Typhimurium

General Information

EC Number General Information Comment Organism
4.1.99.19 physiological function the enzyme is required for the synthesis of the 4-methyl-5-hydroxyethyl-thiazole monophosphate moiety of thiamine diphosphate Salmonella enterica subsp. enterica serovar Typhimurium