EC Number | Cloned (Comment) | Organism |
---|---|---|
3.6.1.13 | expressed in Escherichia coli M15 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.13 | 8-oxo-dGDP | the ADP-ribose cleavage is competitively inhibited by 8-oxo-dGDP (68% relative cleavage efficiency at 0.01 mM) | Homo sapiens | |
3.6.1.13 | 8-oxo-dGMP | the ADP-ribose cleavage is competitively inhibited by 8-oxo-dGMP (89% relative cleavage efficiency at 0.01 mM) | Homo sapiens | |
3.6.1.13 | ADP-ribose | the 8-oxo-dGDP cleavage is competitively inhibited by ADP-ribose (22% relative cleavage efficiency at 0.005 mM) | Homo sapiens | |
3.6.1.13 | AMP | the 8-oxo-dGDP cleavage is competitively inhibited by AMP (30% relative cleavage efficiency at 0.005 mM) | Homo sapiens | |
3.6.1.13 | additional information | no inhibitory effect is observed with 8-oxo-dGMP | Homo sapiens | |
3.6.1.58 | 8-oxo-dGDP | inhibits cleavage of ADP-ribose | Homo sapiens | |
3.6.1.58 | ADP-ribose | inhibits cleavage of 8-oxo-dGTP | Homo sapiens | |
3.6.1.58 | AMP | inhibits cleavage of 8-oxo-dGTP | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.13 | 0.0019 | - |
ADP-ribose | at pH 8.0 and 37°C | Homo sapiens | |
3.6.1.13 | 0.0035 | - |
8-oxo-dGDP | at pH 10.0 and 37°C | Homo sapiens | |
3.6.1.13 | 0.0038 | - |
8-oxo-dGDP | at pH 8.0 and 37°C | Homo sapiens | |
3.6.1.13 | 0.036 | - |
ADP-ribose | at pH 10.0 and 37°C | Homo sapiens | |
3.6.1.58 | 0.0035 | - |
8-oxo-dGDP | pH 10.0, 30°C | Homo sapiens | |
3.6.1.58 | 0.0038 | - |
8-oxo-dGDP | pH 8, 30°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.6.1.13 | Homo sapiens | Q9UKK9 | - |
- |
3.6.1.58 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.6.1.13 | Talon resin column chromatography | Homo sapiens |
3.6.1.58 | - |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.13 | 8-oxo-dGDP + H2O | - |
Homo sapiens | 8-oxo-dGMP + phosphate | - |
? | |
3.6.1.13 | 8-oxo-dGTP + H2O | the enzyme hardly acts on 8-oxo-dGTP | Homo sapiens | ? | - |
? | |
3.6.1.13 | ADP-ribose + H2O | ADP-ribose is a better substrate compared with 8-oxo-dGDP | Homo sapiens | AMP + ribose 5-phosphate | - |
? | |
3.6.1.58 | 8-oxo-dGDP + H2O | ADP-ribose is a better substrate for NUDT5 compared with oxidized guanine nucleotides | Homo sapiens | 8-oxo-dGMP + phosphate | - |
? | |
3.6.1.58 | additional information | the bifunctional enzyme also hydrolyses ADP-ribose to ADP-ribose and ribose 5-phosphate (cf. EC 3.6.1.13) | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.6.1.13 | NUDT5 | - |
Homo sapiens |
3.6.1.58 | NUDT5 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.6.1.58 | 30 | - |
hydrolysis of 8-oxo-dGDP, assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.6.1.13 | 7 | 9 | for cleavage of ADP-ribose | Homo sapiens |
3.6.1.13 | 10 | - |
for cleavage of 8-oxo-dGDP | Homo sapiens |
3.6.1.58 | 10 | - |
cleavage of 8-oxo-dGDP | Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.6.1.58 | 9.5 | 12 | pH 9.5: about 50% of maximal activity, pH 12.0: about 50% of maximal activity | Homo sapiens |