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Literature summary extracted from
- Impact of mutation on proton transfer reactions in ketosteroid isomerase: insights from molecular dynamics simulations (2010), J. Am. Chem. Soc., 132, 7549-7555.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.3.3.1 | D99L | the mutant shows about 10000fold decreased kcat compared to the wild type enzyme | Comamonas testosteroni |
| 5.3.3.1 | Y14F | the mutant shows 100000fold decreased kcat compared to the wild type enzyme | Comamonas testosteroni |
| 5.3.3.1 | Y14F/D99L | the mutant shows 1000000fold decreased kcat compared to the wild type enzyme | Comamonas testosteroni |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.3.1 | Comamonas testosteroni | P00947 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.3.1 | 5-Androstene-3,17-dione | - |
Comamonas testosteroni | 4-Androstene-3,17-dione | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.3.1 | ketosteroid isomerase | - |
Comamonas testosteroni |
| 5.3.3.1 | KSI | - |
Comamonas testosteroni |
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Release 2023.1 (January 2023)
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