BRENDA - Enzyme Database show

Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression

Lu, D.; Han, C.; Wu, T.; Gastroenterology 140, 2084-2094 (2011)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
cholangiocarcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
715100
Homo sapiens
Prostaglandin E2
-
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
cholangiocarcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
715100
Homo sapiens
Prostaglandin E2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
mPGES-1 knockdown delays tumor formation and reduced tumor weight in human cholangiocarcinoma tissue
Homo sapiens
5.3.99.3
metabolism
mPGES-1 is a rate-limiting enzyme that is coupled with cyclooxygenase-2 in the synthesis of prostaglandin E2
Homo sapiens
5.3.99.3
physiological function
overexpression of mPGES-1 in human cholangiocarcinoma cells increases tumor cell proliferation, migration, invasion, and colony formation. mPGES-1 inhibits the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leading to activation of the epidermal growth factor/phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathways in cholangiocarcinoma cells
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
mPGES-1 knockdown delays tumor formation and reduced tumor weight in human cholangiocarcinoma tissue
Homo sapiens
5.3.99.3
metabolism
mPGES-1 is a rate-limiting enzyme that is coupled with cyclooxygenase-2 in the synthesis of prostaglandin E2
Homo sapiens
5.3.99.3
physiological function
overexpression of mPGES-1 in human cholangiocarcinoma cells increases tumor cell proliferation, migration, invasion, and colony formation. mPGES-1 inhibits the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leading to activation of the epidermal growth factor/phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathways in cholangiocarcinoma cells
Homo sapiens