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Literature summary extracted from

  • Takahashi, Y.; Moiseyev, G.; Chen, Y.; Nikolaeva, O.; Ma, J.X.
    An alternative isomerohydrolase in the retinal Mueller cells of a cone-dominant species (2011), FEBS J., 278, 2913-2926.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.64 expressed in 293A cells Danio rerio

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.64 bipyridine in the presence of 1 mM of the metal chelator bipyridine the enzymatic activity of isoform RPE65c is almost completely abolished Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.64 cytosol
-
 Danio rerio 5829
-
3.1.1.64 membrane
-
 Danio rerio 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.64 Fe2+ isoform RPE65a requires iron for its enzymatic activity Danio rerio
3.1.1.64 Fe2+ isoform RPE65c requires iron for its enzymatic activity Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.64 Danio rerio A9C3R8 isoform RPE65c
-
3.1.1.64 Danio rerio Q6PBW5 isoform RPE65a
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.64 additional information isoform RPE65c is not detected in the retinal pigment epithelium Danio rerio
-
3.1.1.64 Mueller cell
-
 Danio rerio
-
3.1.1.64 retina
-
 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.64 2 all-trans-retinyl ester + 2 H2O intrinsic substrate for isoform RPE65c Danio rerio 11-cis-retinol + 13-cis-retinol + 2 a fatty acid
-
 ?
3.1.1.64 all-trans-retinyl ester + H2O
-
 Danio rerio 11-cis-retinol + a fatty acid
-
 ?
3.1.1.64 additional information isoform RPE65c does not generate any detectable 11-cis-retinol from all-trans-retinol Danio rerio ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.64 RPE65a isoform Danio rerio
3.1.1.64 RPE65c isoform Danio rerio

General Information

EC Number General Information Comment Organism
3.1.1.64 physiological function isoform RPE65c is the alternative isomerohydrolase in the intra-retinal visual cycle, providing 11-cis retinal to cone photoreceptors in cone-dominant species Danio rerio