BRENDA - Enzyme Database show

Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase

Barbieri, S.S.; Amadio, P.; Gianellini, S.; Zacchi, E.; Weksler, B.B.; Tremoli, E.; FASEB J. 25, 3731-3740 (2011)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
cardiac endothelial cell
-
Mus musculus
-
5.3.99.3
cardiac endothelium
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
714944
Mus musculus
Prostaglandin E2
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.3
glutathione
-
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
cardiac endothelial cell
-
Mus musculus
-
5.3.99.3
cardiac endothelium
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
714944
Mus musculus
Prostaglandin E2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
inhibition of NADPH-oxidase negatively modulates mPGES-1 expression induced by tobacco smoke/interleukin-1beta. The activation of mPGES-1 is negatively regulated by prostaglandin I2
down
5.3.99.3
Mus musculus
tobacco smoke (EC50 about 5 puffs/l) interacting with IL-1beta (0.002 mg/l) upregulates PGE2 production and mPGES-1 expression, reaching a plateau at 4-6 h
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
inhibition of NADPH-oxidase negatively modulates mPGES-1 expression induced by tobacco smoke/interleukin-1beta. The activation of mPGES-1 is negatively regulated by prostaglandin I2
down
5.3.99.3
Mus musculus
tobacco smoke (EC50 about 5 puffs/l) interacting with IL-1beta (0.002 mg/l) upregulates PGE2 production and mPGES-1 expression, reaching a plateau at 4-6 h
up