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Literature summary extracted from
- delta-Aminolevulinic dehydratase is a proteasome interacting protein (2011), Exp. Mol. Pathol., 91, 485-489.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.2.1.24 | cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.24 | 280000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.24 | 2 5-aminolevulinate | Rattus norvegicus | - |
porphobilinogen + 2 H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.24 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.24 | native enzyme by ammonium sulfate fractionation, anion exchange chromatography, and gel filtration | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.1.24 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.24 | 2 5-aminolevulinate | - |
Rattus norvegicus | porphobilinogen + 2 H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.24 | octamer | - |
Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.24 | ALAD | - |
Rattus norvegicus |
| 4.2.1.24 | delta-aminolevulinic dehydratase | - |
Rattus norvegicus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.2.1.24 | physiological function | delta-aminolevulinate dehydratase is a cytosolic sulfhydryl-containing enzyme that catalyzes the condensation of two molecules of aminolevulinic acid in order to form porphobilinogen, which is the precursor of heme, cytochromes and cobalamines. ALAD plays a role in proteasome S26 activity, which it increases by 75%, overview. The 26S proteasome, a protein complex formed by 32 subunits, performs multiple important proteolytic activities in the cell interacting with the ubiquitination system | Rattus norvegicus |
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Release 2023.1 (January 2023)
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