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Literature summary extracted from
- Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases (2011), Eur. J. Med. Chem., 46, 2852-2860.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.53 | 3,4-dichloroisocoumarin | - |
bovine coronavirus |  |
| 3.1.1.53 | 3,4-dichloroisocoumarin | - |
influenza C virus | |
| 3.1.1.53 | 3,4-dichloroisocoumarin | - |
Murine hepatitis virus | |
| 3.1.1.53 | 3,4-dichloroisocoumarin | - |
Rat sialodacryoadenitis coronavirus | |
| 3.1.1.53 | ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Murine hepatitis virus | |
| 3.1.1.53 | ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Rat sialodacryoadenitis coronavirus | |
| 3.1.1.53 | ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
bovine coronavirus | |
| 3.1.1.53 | ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
influenza C virus | |
| 3.1.1.53 | diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Murine hepatitis virus | |
| 3.1.1.53 | diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
Rat sialodacryoadenitis coronavirus | |
| 3.1.1.53 | diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
bovine coronavirus | |
| 3.1.1.53 | diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | - |
influenza C virus | |
| 3.1.1.53 | additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-O-acetylesterase from Influenza C virus. No inhibition of Bovine coronavirus by ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | bovine coronavirus | |
| 3.1.1.53 | additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-Oacetylesterase from Influenza C virus. No inhibition of Influenza C virus by ammonium (allyl 5-acetamido-3,5-dideoxy-4-O-methyl-D-glycero-a-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-4-O-(P-methylphosphonyl)-D-glycero-a-d-galacto-2-nonulopyranosidonate) | influenza C virus | |
| 3.1.1.53 | additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-O-acetylesterase from Influenza C virus. No inhibition of Mouse hepatitis virus strain S by ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | Murine hepatitis virus | |
| 3.1.1.53 | additional information | synthesis and evaluation of a series of sialosides modified at the 4- and 9-hydroxy group for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses, overview. While no inhibition of the sialate-4-O-acetylesterases from Mouse hepatitis virus strain S or Sialodacryoadenitis virus is found, a 9-O-methyl derivative displays inhibitory activity against recombinant sialate-9-O-acetylesterase from Influenza C virus. No inhibition of Rat sialoadacryoadenitis coronavirus by ammonium (allyl 5-acetamido-9-O-methyl-3,5-dideoxy-dglycero-alpha-D-galacto-2-nonulopyranosidonate) and diammonium (allyl 5-acetamido-3,5-dideoxy-9-O-(P-methylphosphonyl)-D-glycero-alpha-D-galacto-2-nonulopyranosidonate) | Rat sialodacryoadenitis coronavirus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.53 | additional information | bovine coronavirus | the enzyme of Bovine coronavirus exhibits sialate-9-O-acetylesterase specificity | ? | - |
? | |
| 3.1.1.53 | additional information | influenza C virus | the enzyme of Influenza C virus exhibits sialate-9-O-acetylesterase specificity | ? | - |
? | |
| 3.1.1.53 | additional information | Murine hepatitis virus | the enzyme of Influenzy C virus exhibits sialate-4-O-acetylesterase specificity | ? | - |
? | |
| 3.1.1.53 | additional information | Rat sialodacryoadenitis coronavirus | the enzyme of Rat sialoadacryoadenitis coronavirus exhibits sialate-4-O-acetylesterase specificity | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.53 | bovine coronavirus | - |
BcoV | - |
| 3.1.1.53 | influenza C virus | - |
- |
- |
| 3.1.1.53 | Murine hepatitis virus | - |
- |
- |
| 3.1.1.53 | Rat sialodacryoadenitis coronavirus | - |
SDAV | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.53 | 4-nitrophenyl acetate + H2O | - |
influenza C virus | 4-nitrophenol + acetate | - |
? | |
| 3.1.1.53 | 4-nitrophenyl acetate + H2O | - |
Murine hepatitis virus | 4-nitrophenol + acetate | - |
? | |
| 3.1.1.53 | 4-nitrophenyl acetate + H2O | - |
bovine coronavirus | 4-nitrophenol + acetate | - |
? | |
| 3.1.1.53 | 4-nitrophenyl acetate + H2O | - |
Rat sialodacryoadenitis coronavirus | 4-nitrophenol + acetate | - |
? | |
| 3.1.1.53 | additional information | the enzyme of Bovine coronavirus exhibits sialate-9-O-acetylesterase specificity | bovine coronavirus | ? | - |
? | |
| 3.1.1.53 | additional information | the enzyme of Influenza C virus exhibits sialate-9-O-acetylesterase specificity | influenza C virus | ? | - |
? | |
| 3.1.1.53 | additional information | the enzyme of Influenzy C virus exhibits sialate-4-O-acetylesterase specificity | Murine hepatitis virus | ? | - |
? | |
| 3.1.1.53 | additional information | the enzyme of Rat sialoadacryoadenitis coronavirus exhibits sialate-4-O-acetylesterase specificity | Rat sialodacryoadenitis coronavirus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.53 | 4-SOAE | - |
influenza C virus |
| 3.1.1.53 | 4-SOAE | - |
Murine hepatitis virus |
| 3.1.1.53 | 4-SOAE | - |
bovine coronavirus |
| 3.1.1.53 | 4-SOAE | - |
Rat sialodacryoadenitis coronavirus |
| 3.1.1.53 | 9-SOAE | - |
influenza C virus |
| 3.1.1.53 | 9-SOAE | - |
Murine hepatitis virus |
| 3.1.1.53 | 9-SOAE | - |
bovine coronavirus |
| 3.1.1.53 | 9-SOAE | - |
Rat sialodacryoadenitis coronavirus |
| 3.1.1.53 | sialate-4-O-acetylesterase | - |
influenza C virus |
| 3.1.1.53 | sialate-4-O-acetylesterase | - |
Murine hepatitis virus |
| 3.1.1.53 | sialate-4-O-acetylesterase | - |
bovine coronavirus |
| 3.1.1.53 | sialate-4-O-acetylesterase | - |
Rat sialodacryoadenitis coronavirus |
| 3.1.1.53 | sialate-9-O-acetylesterase | - |
influenza C virus |
| 3.1.1.53 | sialate-9-O-acetylesterase | - |
Murine hepatitis virus |
| 3.1.1.53 | sialate-9-O-acetylesterase | - |
bovine coronavirus |
| 3.1.1.53 | sialate-9-O-acetylesterase | - |
Rat sialodacryoadenitis coronavirus |
| 3.1.1.53 | sialate-O-acetylesterase | - |
influenza C virus |
| 3.1.1.53 | sialate-O-acetylesterase | - |
Murine hepatitis virus |
| 3.1.1.53 | sialate-O-acetylesterase | - |
bovine coronavirus |
| 3.1.1.53 | sialate-O-acetylesterase | - |
Rat sialodacryoadenitis coronavirus |
| 3.1.1.53 | SOAE | - |
influenza C virus |
| 3.1.1.53 | SOAE | - |
Murine hepatitis virus |
| 3.1.1.53 | SOAE | - |
bovine coronavirus |
| 3.1.1.53 | SOAE | - |
Rat sialodacryoadenitis coronavirus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.53 | 22 | - |
assay at room temperature | influenza C virus |
| 3.1.1.53 | 22 | - |
assay at room temperature | Murine hepatitis virus |
| 3.1.1.53 | 22 | - |
assay at room temperature | bovine coronavirus |
| 3.1.1.53 | 22 | - |
assay at room temperature | Rat sialodacryoadenitis coronavirus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.53 | 7.4 | - |
assay at | influenza C virus |
| 3.1.1.53 | 7.4 | - |
assay at | Murine hepatitis virus |
| 3.1.1.53 | 7.4 | - |
assay at | bovine coronavirus |
| 3.1.1.53 | 7.4 | - |
assay at | Rat sialodacryoadenitis coronavirus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.1.53 | physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Bovine coronavirus exhibits sialate-9-O-acetylesterase specificity | bovine coronavirus |
| 3.1.1.53 | physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Influenza C virus exhibits sialate-9-O-acetylesterase specificity | influenza C virus |
| 3.1.1.53 | physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Mouse hepatitis virus strain S exhibits sialate-4-O-acetylesterase specificity | Murine hepatitis virus |
| 3.1.1.53 | physiological function | besides sialidases, the haemagglutinin-esterases of Influenza C virus, Isavirus, Betacoronaviruses and Toroviruses represent another class of receptor-destroying enzymes, RDEs. They are sialate-O-acetylesterases, SOAE, hydrolysing O-acetyl esters of O-acetylated sialic acid derivatives as sialate-4-O-acetylesterases, 4-SOAE, and sialate-9-O-acetylesterases, 9-SOAE. The enzyme of Rat sialoadacryoadenitis coronavirus exhibits sialate-4-O-acetylesterase specificity | Rat sialodacryoadenitis coronavirus |
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