EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.1 | L-adrenaline | - |
Saccharomyces cerevisiae | |
4.2.1.1 | additional information | L-adrenaline and some piperazines incorporating aminoethyl moieties were the most effective scCA activators | Saccharomyces cerevisiae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.1 | 4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide | - |
Saccharomyces cerevisiae | |
4.2.1.1 | bromide | - |
Saccharomyces cerevisiae | |
4.2.1.1 | Iodide | - |
Saccharomyces cerevisiae | |
4.2.1.1 | additional information | bromide, iodide and sulfamide, are the best anion inhibitors, with Ki values of 0.0087-0.0108 mM. Benzenesulfonamides substituted in 2-, 4- and 3,4-positions with amino, alkyl, halogeno and hydroxyalkyl moieties have Ki values in the range of 0.000976-0.01845 mM. Better inhibition with Ki values in the range of 154-654 nM is observed for benzenesulfonamides incorporating aminoalkyl/carboxyalkyl moieties or halogenosulfanilamides, benzene-1,3-disulfonamides, simple heterocyclic sulfonamides and sulfanilyl-sulfonamides. The clinically used sulfonamides/sulfamates, e.g. acetazolamide, ethoxzolamide, methazolamide, dorzolamide, topiramate, celecoxib, generally show effective scCA inhibitory activity, with Ki values in the range of 82.6-133 nM, overview | Saccharomyces cerevisiae | |
4.2.1.1 | sulfamide | - |
Saccharomyces cerevisiae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.1 | H2CO3 | Saccharomyces cerevisiae | - |
CO2 + H2O | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.1 | Saccharomyces cerevisiae | - |
gene Nce103 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.1 | H2CO3 | - |
Saccharomyces cerevisiae | CO2 + H2O | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.1 | beta-carbonic anhydrase | - |
Saccharomyces cerevisiae |
4.2.1.1 | scCA | - |
Saccharomyces cerevisiae |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 940000 | - |
CO2 | pH not specified in the publication, temperature not specified in the publication | Saccharomyces cerevisiae |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 0.0000151 | - |
4-(2-amino-pyrimidin-4-yl)-benzenesulfonamide | pH not specified in the publication, temperature not specified in the publication | Saccharomyces cerevisiae |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 98000 | - |
CO2 | pH not specified in the publication, temperature not specified in the publication | Saccharomyces cerevisiae |