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Literature summary extracted from

  • Langella, E.; Pierre, S.; Ghattas, W.; Giorgi, M.; Reglier, M.; Saviano, M.; Esposito, L.; Hardre, R.
    Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors (2010), ChemMedChem, 5, 1568-1576.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.3 (2E)-4-oxo-4-phenylbut-2-enoic acid
-
 Sus scrofa
1.14.17.3 (3E)-4-(4-methoxyphenyl)but-3-enoic acid
-
 Sus scrofa
1.14.17.3 (3E)-4-(4-methylphenyl)but-3-enoic acid
-
 Sus scrofa
1.14.17.3 (3E)-4-[3-(benzyloxy)-4-methoxyphenyl]but-3-enoic acid
-
 Sus scrofa
1.14.17.3 (3E)-4-[4-(benzyloxy)phenyl]but-3-enoic acid
-
 Sus scrofa
1.14.17.3 4-Phenyl-3-butenoic acid
-
 Sus scrofa
1.14.17.3 [(1R,2S)-2-phenylcyclopropyl]acetic acid
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.3 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.17.3 membrane bound form Sus scrofa

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.17.3 0.0014
-
 pH 6.5, 37°C Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.3 N-DANSYL-D-Tyr-L-Val-Gly + ascorbate + O2
-
 Sus scrofa N-DANSYL-D-Tyr-L-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?
1.14.17.3 peptidylglycine + ascorbate + O2
-
 Sus scrofa peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.3 peptidylglycine alpha-hydroxylating monooxygenase the bifunctional enzyme peptidylglycine alpha-amidating monooxygenase possesses two different catalytic domains: the peptidylglycine alpha-hydroxylating monooxygenase domain and the peptidyl alpha-hydroxyglycine alpha-amidating lyase domain Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.17.3 0.0039
-
 (3E)-4-[3-(benzyloxy)-4-methoxyphenyl]but-3-enoic acid pH 6.5, 37°C Sus scrofa
1.14.17.3 0.0057
-
 (3E)-4-(4-methylphenyl)but-3-enoic acid pH 6.5, 37°C Sus scrofa
1.14.17.3 0.015
-
 (3E)-4-(4-methoxyphenyl)but-3-enoic acid pH 6.5, 37°C Sus scrofa
1.14.17.3 0.019
-
 4-Phenyl-3-butenoic acid pH 6.5, 37°C Sus scrofa
1.14.17.3 0.019
-
 (3E)-4-[4-(benzyloxy)phenyl]but-3-enoic acid pH 6.5, 37°C Sus scrofa
1.14.17.3 0.131
-
 [(1R,2S)-2-phenylcyclopropyl]acetic acid pH 6.5, 37°C Sus scrofa
1.14.17.3 0.44
-
 (2E)-4-oxo-4-phenylbut-2-enoic acid pH 6.5, 37°C Sus scrofa