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Literature summary extracted from

  • Sentuerk, M.; Guelcin, I.; Beydemir, S.; Kuefrevioglu, O.I.; Supuran, C.T.
    In vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds (2011), Chem. Biol. Drug Des., 77, 494-499.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide
-
 Homo sapiens
4.2.1.1 catechin a competitive inhibitor with 4-nitrophenylacetate as substrate Homo sapiens
4.2.1.1 curcumin a competitive inhibitor with 4-nitrophenylacetate as substrate Homo sapiens
4.2.1.1 dobutamin a competitive inhibitor with 4-nitrophenylacetate as substrate Homo sapiens
4.2.1.1 additional information some natural phenols show effective hCA II inhibitory effects, in the same range as the clinically used sulfonamide acetazolamide, and might be used as leads for generating enzyme inhibitors possibly targeting other CA isozymes Homo sapiens
4.2.1.1 resveratrol a competitive inhibitor with 4-nitrophenylacetate as substrate Homo sapiens
4.2.1.1 silymarin a competitive inhibitor with 4-nitrophenylacetate as substrate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 cytosol isozymes carbonic anhydrase I and II Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Homo sapiens
-
 isozymes carbonic anhydrase I and II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.1 native hCA I and hCA II from erythrocytes by aniline-sulfanylamide affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.1 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 H2CO3
-
 Homo sapiens CO2 + H2O
-
 r
4.2.1.1 additional information the enzyme shows esterase assay with 4-nitrophenyl acetate as substrate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 carbonic anhydrase I
-
 Homo sapiens
4.2.1.1 carbonic anhydrase II
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.1 additional information
-
 esterase activity assay at 25°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.1 additional information
-
 esterase activity assay at pH 7.4 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 additional information
-
 additional information Ki values for natural phenols with isozymes hCA I and hCA II in the esterase activity assay, overview Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.1.1 additional information
-
 IC50 values for natural phenols with isozymes hCA I and hCA II in the esterase activity assay, overview Homo sapiens additional information