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Literature summary extracted from
- Triosephosphate isomerase: a highly evolved biocatalyst (2010), Cell. Mol. Life Sci., 67, 3961-3982.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.3.1.1 | E104D | in patients homozygous for this mutation, only 2-20% of TIM catalytic activity is left | Homo sapiens |
| 5.3.1.1 | I170V | the mutation is asociated with a mild form of TIM deficiency | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Bartonella henselae |  |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Caenorhabditis elegans | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Entamoeba histolytica | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Escherichia coli | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Gallus gallus | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Geobacillus stearothermophilus | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Giardia intestinalis | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Helicobacter pylori | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Homo sapiens | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Leishmania mexicana | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Methanocaldococcus jannaschii | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Moritella marina | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Mycobacterium tuberculosis | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Oryctolagus cuniculus | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Plasmodium falciparum | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Pyrococcus woesei | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Saccharomyces cerevisiae | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Tenebrio molitor | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Thermoproteus tenax | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Thermotoga maritima | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Trypanosoma brucei brucei | |
| 5.3.1.1 | bromohydroxyacetone phosphate | suicide inhibitor | Trypanosoma cruzi | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Bartonella henselae | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Caenorhabditis elegans | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Entamoeba histolytica | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Escherichia coli | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Gallus gallus | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Geobacillus stearothermophilus | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Giardia intestinalis | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Helicobacter pylori | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Homo sapiens | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Leishmania mexicana | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Methanocaldococcus jannaschii | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Moritella marina | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Mycobacterium tuberculosis | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Oryctolagus cuniculus | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Plasmodium falciparum | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Pyrococcus woesei | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Saccharomyces cerevisiae | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Tenebrio molitor | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Thermoproteus tenax | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Thermotoga maritima | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Trypanosoma brucei brucei | |
| 5.3.1.1 | DL-glycidol phosphate | suicide inhibitor | Trypanosoma cruzi | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.1.1 | cytosol | - |
Homo sapiens | 5829 | - |
| 5.3.1.1 | cytosol | - |
Helicobacter pylori | 5829 | - |
| 5.3.1.1 | cytosol | - |
Gallus gallus | 5829 | - |
| 5.3.1.1 | cytosol | - |
Tenebrio molitor | 5829 | - |
| 5.3.1.1 | cytosol | - |
Leishmania mexicana | 5829 | - |
| 5.3.1.1 | cytosol | - |
Plasmodium falciparum | 5829 | - |
| 5.3.1.1 | cytosol | - |
Giardia intestinalis | 5829 | - |
| 5.3.1.1 | cytosol | - |
Methanocaldococcus jannaschii | 5829 | - |
| 5.3.1.1 | cytosol | - |
Moritella marina | 5829 | - |
| 5.3.1.1 | cytosol | - |
Mycobacterium tuberculosis | 5829 | - |
| 5.3.1.1 | cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| 5.3.1.1 | cytosol | - |
Pyrococcus woesei | 5829 | - |
| 5.3.1.1 | cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
| 5.3.1.1 | cytosol | - |
Trypanosoma brucei brucei | 5829 | - |
| 5.3.1.1 | cytosol | - |
Thermotoga maritima | 5829 | - |
| 5.3.1.1 | cytosol | - |
Thermoproteus tenax | 5829 | - |
| 5.3.1.1 | cytosol | - |
Bartonella henselae | 5829 | - |
| 5.3.1.1 | cytosol | - |
Geobacillus stearothermophilus | 5829 | - |
| 5.3.1.1 | cytosol | - |
Caenorhabditis elegans | 5829 | - |
| 5.3.1.1 | cytosol | - |
Escherichia coli | 5829 | - |
| 5.3.1.1 | cytosol | - |
Entamoeba histolytica | 5829 | - |
| 5.3.1.1 | glycosome | - |
Trypanosoma cruzi | 20015 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.1.1 | Bartonella henselae | Q8L1Z5 | - |
- |
| 5.3.1.1 | Caenorhabditis elegans | Q10657 | - |
- |
| 5.3.1.1 | Entamoeba histolytica | O02611 | - |
- |
| 5.3.1.1 | Escherichia coli | P0A858 | - |
- |
| 5.3.1.1 | Gallus gallus | P00940 | - |
- |
| 5.3.1.1 | Geobacillus stearothermophilus | P00943 | - |
- |
| 5.3.1.1 | Giardia intestinalis | P36186 | - |
- |
| 5.3.1.1 | Helicobacter pylori | P56076 | - |
- |
| 5.3.1.1 | Homo sapiens | P60174 | - |
- |
| 5.3.1.1 | Leishmania mexicana | P48499 | - |
- |
| 5.3.1.1 | Methanocaldococcus jannaschii | Q58923 | - |
- |
| 5.3.1.1 | Moritella marina | P50921 | - |
- |
| 5.3.1.1 | Mycobacterium tuberculosis | P9WG43 | - |
- |
| 5.3.1.1 | Mycobacterium tuberculosis H37Rv | P9WG43 | - |
- |
| 5.3.1.1 | Oryctolagus cuniculus | P00939 | - |
- |
| 5.3.1.1 | Plasmodium falciparum | Q07412 | - |
- |
| 5.3.1.1 | Pyrococcus woesei | P62003 | - |
- |
| 5.3.1.1 | Saccharomyces cerevisiae | P00942 | - |
- |
| 5.3.1.1 | Tenebrio molitor | Q8MPF2 | - |
- |
| 5.3.1.1 | Thermoproteus tenax | Q8NKN9 | - |
- |
| 5.3.1.1 | Thermotoga maritima | P36204 | bifunctional enzyme, phosphoglycerate kinase/triosephosphate isomerase | - |
| 5.3.1.1 | Trypanosoma brucei brucei | P04789 | - |
- |
| 5.3.1.1 | Trypanosoma cruzi | P52270 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Homo sapiens | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Helicobacter pylori | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Gallus gallus | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Tenebrio molitor | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Leishmania mexicana | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Plasmodium falciparum | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Giardia intestinalis | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Methanocaldococcus jannaschii | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Moritella marina | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Mycobacterium tuberculosis | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Oryctolagus cuniculus | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Pyrococcus woesei | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Saccharomyces cerevisiae | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Trypanosoma brucei brucei | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Trypanosoma cruzi | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Thermotoga maritima | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Thermoproteus tenax | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Bartonella henselae | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Geobacillus stearothermophilus | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Caenorhabditis elegans | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Escherichia coli | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Entamoeba histolytica | dihydroxyacetone phosphate | - |
r | |
| 5.3.1.1 | D-glyceraldehyde 3-phosphate | - |
Mycobacterium tuberculosis H37Rv | dihydroxyacetone phosphate | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Homo sapiens |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Helicobacter pylori |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Gallus gallus |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Tenebrio molitor |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Leishmania mexicana |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Plasmodium falciparum |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Giardia intestinalis |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Methanocaldococcus jannaschii |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Moritella marina |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Mycobacterium tuberculosis |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Oryctolagus cuniculus |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Pyrococcus woesei |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Saccharomyces cerevisiae |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Trypanosoma brucei brucei |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Trypanosoma cruzi |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Thermotoga maritima |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Thermoproteus tenax |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Bartonella henselae |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Geobacillus stearothermophilus |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Caenorhabditis elegans |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Escherichia coli |
| 5.3.1.1 | dimer | X-ray crystallography, only the TIM dimer is fully active | Entamoeba histolytica |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.1.1 | TIM | - |
Homo sapiens |
| 5.3.1.1 | TIM | - |
Helicobacter pylori |
| 5.3.1.1 | TIM | - |
Gallus gallus |
| 5.3.1.1 | TIM | - |
Tenebrio molitor |
| 5.3.1.1 | TIM | - |
Leishmania mexicana |
| 5.3.1.1 | TIM | - |
Plasmodium falciparum |
| 5.3.1.1 | TIM | - |
Giardia intestinalis |
| 5.3.1.1 | TIM | - |
Methanocaldococcus jannaschii |
| 5.3.1.1 | TIM | - |
Moritella marina |
| 5.3.1.1 | TIM | - |
Mycobacterium tuberculosis |
| 5.3.1.1 | TIM | - |
Oryctolagus cuniculus |
| 5.3.1.1 | TIM | - |
Pyrococcus woesei |
| 5.3.1.1 | TIM | - |
Saccharomyces cerevisiae |
| 5.3.1.1 | TIM | - |
Trypanosoma brucei brucei |
| 5.3.1.1 | TIM | - |
Trypanosoma cruzi |
| 5.3.1.1 | TIM | - |
Thermotoga maritima |
| 5.3.1.1 | TIM | - |
Thermoproteus tenax |
| 5.3.1.1 | TIM | - |
Bartonella henselae |
| 5.3.1.1 | TIM | - |
Geobacillus stearothermophilus |
| 5.3.1.1 | TIM | - |
Caenorhabditis elegans |
| 5.3.1.1 | TIM | - |
Escherichia coli |
| 5.3.1.1 | TIM | - |
Entamoeba histolytica |
| 5.3.1.1 | Triosephosphate isomerase | - |
Homo sapiens |
| 5.3.1.1 | Triosephosphate isomerase | - |
Helicobacter pylori |
| 5.3.1.1 | Triosephosphate isomerase | - |
Gallus gallus |
| 5.3.1.1 | Triosephosphate isomerase | - |
Tenebrio molitor |
| 5.3.1.1 | Triosephosphate isomerase | - |
Leishmania mexicana |
| 5.3.1.1 | Triosephosphate isomerase | - |
Plasmodium falciparum |
| 5.3.1.1 | Triosephosphate isomerase | - |
Giardia intestinalis |
| 5.3.1.1 | Triosephosphate isomerase | - |
Methanocaldococcus jannaschii |
| 5.3.1.1 | Triosephosphate isomerase | - |
Moritella marina |
| 5.3.1.1 | Triosephosphate isomerase | - |
Mycobacterium tuberculosis |
| 5.3.1.1 | Triosephosphate isomerase | - |
Oryctolagus cuniculus |
| 5.3.1.1 | Triosephosphate isomerase | - |
Pyrococcus woesei |
| 5.3.1.1 | Triosephosphate isomerase | - |
Saccharomyces cerevisiae |
| 5.3.1.1 | Triosephosphate isomerase | - |
Trypanosoma brucei brucei |
| 5.3.1.1 | Triosephosphate isomerase | - |
Trypanosoma cruzi |
| 5.3.1.1 | Triosephosphate isomerase | - |
Thermotoga maritima |
| 5.3.1.1 | Triosephosphate isomerase | - |
Thermoproteus tenax |
| 5.3.1.1 | Triosephosphate isomerase | - |
Bartonella henselae |
| 5.3.1.1 | Triosephosphate isomerase | - |
Geobacillus stearothermophilus |
| 5.3.1.1 | Triosephosphate isomerase | - |
Caenorhabditis elegans |
| 5.3.1.1 | Triosephosphate isomerase | - |
Escherichia coli |
| 5.3.1.1 | Triosephosphate isomerase | - |
Entamoeba histolytica |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Homo sapiens |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Helicobacter pylori |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Gallus gallus |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Tenebrio molitor |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Leishmania mexicana |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Plasmodium falciparum |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Giardia intestinalis |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Methanocaldococcus jannaschii |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Moritella marina |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Mycobacterium tuberculosis |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Oryctolagus cuniculus |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Pyrococcus woesei |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Saccharomyces cerevisiae |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Trypanosoma brucei brucei |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Trypanosoma cruzi |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Thermotoga maritima |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Thermoproteus tenax |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Bartonella henselae |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Geobacillus stearothermophilus |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Caenorhabditis elegans |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Escherichia coli |
| 5.3.1.1 | 8 | - |
optimum is near pH 8.0 | Entamoeba histolytica |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.3.1.1 | malfunction | TIM deficiency is the only human glycolytic deficiency disease which is lethal, usually in early childhood. The disease symptoms concern hemolytic anemia but also neurological disorders | Homo sapiens |
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