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Literature summary extracted from

  • Kong, D.; Zhu, Y.; Wu, H.; Cheng, X.; Liang, H.; Ling, H.Q.
    AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana (2008), Cell Res., 18, 566-576.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.99.17 heterologous expression of AtTHIC can functionally complement the thiC knock-out mutant of Escherichia coli Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.99.17 chloroplast
-
 Arabidopsis thaliana 9507
-
4.1.99.17 plastid
-
 Arabidopsis thaliana 9536
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine Arabidopsis thaliana the enzyme is involved in the biosynthesis of thiamine diphosphate 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.17 Arabidopsis thaliana O82392
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.99.17 flower strong expression Arabidopsis thaliana
-
4.1.99.17 leaf strong expression Arabidopsis thaliana
-
4.1.99.17 silique strong expression Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine
-
 Arabidopsis thaliana 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine the enzyme is involved in the biosynthesis of thiamine diphosphate Arabidopsis thaliana 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.99.17 AtTHIC
-
 Arabidopsis thaliana

Expression

EC Number Organism Comment Expression
4.1.99.17 Arabidopsis thaliana downregulation of AtTHIC expression by T-DNA insertion at its promoter region results in a drastic reduction of thiamine content in plants and the knock-down mutant thic1 shows albino (white leaves) and lethal phenotypes under the normal culture conditions down

General Information

EC Number General Information Comment Organism
4.1.99.17 malfunction downregulation of AtTHIC expression by T-DNA insertion at its promoter region results in a drastic reduction of thiamine content in plants and the knock-down mutant thic1 shows albino (white leaves) and lethal phenotypes under the normal culture conditions Arabidopsis thaliana
4.1.99.17 physiological function the enzyme is involved in the biosynthesis of thiamine diphosphate Arabidopsis thaliana