EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.1 | expressed in Spodoptera frugiperda cells and in U373MG cells | Homo sapiens |
3.1.1.1 | expressed in Spodoptera frugiperda cells and in U373MG cells | Oryctolagus cuniculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.1 | 1,2-dicyclohexylethane-1,2-dione | - |
Homo sapiens | |
3.1.1.1 | 1,2-dicyclohexylethane-1,2-dione | - |
Oryctolagus cuniculus | |
3.1.1.1 | 1,4-dibromo-1,4-diphenyl butane-2,3-dione | irreversible inhibition | Homo sapiens | |
3.1.1.1 | 1,4-dibromo-1,4-diphenyl butane-2,3-dione | irreversible inhibition | Oryctolagus cuniculus | |
3.1.1.1 | benzil | irreversible inhibition | Homo sapiens | |
3.1.1.1 | benzil | irreversible inhibition | Oryctolagus cuniculus | |
3.1.1.1 | decane-5,6-dione | - |
Homo sapiens | |
3.1.1.1 | decane-5,6-dione | - |
Oryctolagus cuniculus | |
3.1.1.1 | dodecane-6,7-dione | - |
Homo sapiens | |
3.1.1.1 | dodecane-6,7-dione | - |
Oryctolagus cuniculus | |
3.1.1.1 | hexadecane-8,9-dione | - |
Homo sapiens | |
3.1.1.1 | hexadecane-8,9-dione | - |
Oryctolagus cuniculus | |
3.1.1.1 | additional information | not inhibited by butane-2,3-dione, hexane 3,4-dione, oxanilide, S1,S2-diphenyl ethane bis(thioate), diphenyl ethanedioate, 1,4-diphenylbutane-2,3-dione, and 1-bromo-1,4-diphenyl butane-2,3-dione | Homo sapiens | |
3.1.1.1 | additional information | not inhibited by butane-2,3-dione, hexane 3,4-dione, oxanilide, S1,S2-diphenyl ethane bis(thioate), diphenyl ethanedioate, 1,4-diphenylbutane-2,3-dione, and 1-bromo-1,4-diphenyl butane-2,3-dione | Oryctolagus cuniculus | |
3.1.1.1 | octadecane-9,10-dione | - |
Homo sapiens | |
3.1.1.1 | octadecane-9,10-dione | - |
Oryctolagus cuniculus | |
3.1.1.1 | octane-4,5-dione | - |
Homo sapiens | |
3.1.1.1 | octane-4,5-dione | - |
Oryctolagus cuniculus | |
3.1.1.1 | phenyl-1,2-butanedione | - |
Homo sapiens | |
3.1.1.1 | phenyl-1,2-butanedione | - |
Oryctolagus cuniculus | |
3.1.1.1 | phenyl-1,2-heptanedione | - |
Homo sapiens | |
3.1.1.1 | phenyl-1,2-heptanedione | - |
Oryctolagus cuniculus | |
3.1.1.1 | phenyl-1,2-hexanedione | - |
Homo sapiens | |
3.1.1.1 | phenyl-1,2-hexanedione | - |
Oryctolagus cuniculus | |
3.1.1.1 | phenyl-1,2-octanedione | - |
Homo sapiens | |
3.1.1.1 | phenyl-1,2-octanedione | - |
Oryctolagus cuniculus | |
3.1.1.1 | phenyl-1,2-pentanedione | - |
Homo sapiens | |
3.1.1.1 | phenyl-1,2-pentanedione | - |
Oryctolagus cuniculus | |
3.1.1.1 | phenyl-1,2-propanedione | - |
Homo sapiens | |
3.1.1.1 | phenyl-1,2-propanedione | - |
Oryctolagus cuniculus | |
3.1.1.1 | tetradecane-7,8-dione | - |
Homo sapiens | |
3.1.1.1 | tetradecane-7,8-dione | - |
Oryctolagus cuniculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.1 | Homo sapiens | - |
- |
- |
3.1.1.1 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.1 | intestine | - |
Homo sapiens | - |
3.1.1.1 | liver | - |
Homo sapiens | - |
3.1.1.1 | liver | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.1 | 4-methylumbelliferyl acetate + H2O | - |
Homo sapiens | 4-methylumbelliferone + acetate | - |
? | |
3.1.1.1 | 4-methylumbelliferyl acetate + H2O | - |
Oryctolagus cuniculus | 4-methylumbelliferone + acetate | - |
? | |
3.1.1.1 | 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
3.1.1.1 | 4-nitrophenyl acetate + H2O | - |
Oryctolagus cuniculus | 4-nitrophenol + acetate | - |
? | |
3.1.1.1 | CPT-11 + H2O | - |
Homo sapiens | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? | |
3.1.1.1 | CPT-11 + H2O | - |
Oryctolagus cuniculus | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.1 | CE1 | carboxylesterase from liver | Homo sapiens |
3.1.1.1 | ICE | carboxylesterase from intestine | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.1 | 0.00000084 | - |
octadecane-9,10-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.00000219 | - |
phenyl-1,2-octanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000003 | - |
dodecane-6,7-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000048 | - |
tetradecane-7,8-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000005 | - |
1,2-dicyclohexylethane-1,2-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000057 | - |
octadecane-9,10-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000065 | - |
hexadecane-8,9-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.00000665 | - |
phenyl-1,2-heptanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000076 | - |
hexadecane-8,9-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000009 | - |
octadecane-9,10-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.000015 | - |
benzil | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000151 | - |
tetradecane-7,8-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.0000205 | - |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.0000256 | - |
hexadecane-8,9-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000261 | - |
phenyl-1,2-hexanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000027 | - |
1,2-dicyclohexylethane-1,2-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.0000281 | - |
phenyl-1,2-octanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.0000287 | - |
phenyl-1,2-octanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000386 | - |
dodecane-6,7-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.000045 | - |
benzil | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000455 | - |
phenyl-1,2-heptanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000466 | - |
decane-5,6-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000577 | - |
dodecane-6,7-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000072 | - |
1,2-dicyclohexylethane-1,2-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000727 | - |
phenyl-1,2-hexanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0000764 | - |
tetradecane-7,8-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000102 | - |
phenyl-1,2-pentanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000102 | - |
benzil | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.00011 | - |
phenyl-1,2-heptanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.000189 | - |
decane-5,6-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000334 | - |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000337 | - |
phenyl-1,2-hexanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.000401 | - |
phenyl-1,2-pentanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.000944 | - |
decane-5,6-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.00155 | - |
phenyl-1,2-butanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.00184 | - |
phenyl-1,2-propanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.00242 | - |
phenyl-1,2-butanedione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.00271 | - |
phenyl-1,2-pentanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.004493 | - |
phenyl-1,2-propanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.00467 | - |
octane-4,5-dione | enzyme from intestine (iCE), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.00527 | - |
phenyl-1,2-propanedione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.008 | - |
1,4-dibromo-1,4-diphenyl butane-2,3-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.00806 | - |
octane-4,5-dione | enzyme from liver (CE1), in 50 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | |
3.1.1.1 | 0.0125 | - |
phenyl-1,2-butanedione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus | |
3.1.1.1 | 0.01778 | - |
octane-4,5-dione | in 50 mM HEPES buffer, pH 7.4, at 37°C | Oryctolagus cuniculus |