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Literature summary extracted from

  • Kaku, T.; Tsujimoto, S.; Matsunaga, N.; Tanaka, T.; Hara, T.; Yamaoka, M.; Kusaka, M.; Tasaka, A.
    17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors (2011), Bioorg. Med. Chem., 19, 2428-2442.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 (+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
-
 Homo sapiens
1.14.14.19 (+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
-
 Rattus norvegicus
1.14.14.19 (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 (-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
-
 Homo sapiens
1.14.14.19 (-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
-
 Rattus norvegicus
1.14.14.19 1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol
-
 Homo sapiens
1.14.14.19 1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Homo sapiens
1.14.14.19 1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
-
 Rattus norvegicus
1.14.14.19 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide
-
 Homo sapiens
1.14.14.19 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide
-
 Rattus norvegicus
1.14.14.19 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide
-
 Homo sapiens
1.14.14.19 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide
-
 Rattus norvegicus
1.14.14.19 abiraterone acetate
-
 Homo sapiens
1.14.14.19 abiraterone acetate
-
 Rattus norvegicus
1.14.14.19 N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea
-
 Homo sapiens
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea
-
 Rattus norvegicus
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide
-
 Homo sapiens
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide
-
 Homo sapiens
1.14.14.19 N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide
-
 Rattus norvegicus
1.14.14.19 N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
-
 Homo sapiens
1.14.14.19 N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
-
 Rattus norvegicus
1.14.14.19 YM-116
-
 Homo sapiens
1.14.14.19 YM-116
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.19 microsome
-
 Homo sapiens
-
-
1.14.14.19 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-
1.14.14.19 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 17alpha-hydroxyprogesterone + AH2 + O2
-
 Homo sapiens ?
-
 ?
1.14.14.19 17alpha-hydroxyprogesterone + AH2 + O2
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 17,20-lyase
-
 Homo sapiens
1.14.14.19 17,20-lyase
-
 Rattus norvegicus
1.14.14.19 CYP17A1
-
 Homo sapiens
1.14.14.19 CYP17A1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.19 cytochrome b5
-
 Homo sapiens
1.14.14.19 cytochrome b5
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.14.19 0.0000083
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.00001
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol
1.14.14.19 0.000014
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000015
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000017
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000018
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000019
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000019
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000019
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000021
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea
1.14.14.19 0.000022
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000024
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000024
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide
1.14.14.19 0.000024
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea
1.14.14.19 0.000025
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000026
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000026
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens (-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
1.14.14.19 0.000027
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000028
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000028
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000029
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000033
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000033
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000033
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus (-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
1.14.14.19 0.000036
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
1.14.14.19 0.000038
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.00004
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000044
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide
1.14.14.19 0.000045
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000049
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000049
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide
1.14.14.19 0.000053
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
1.14.14.19 0.000054
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol
1.14.14.19 0.000062
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000071
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide
1.14.14.19 0.000077
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000081
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.000092
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens (+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide
1.14.14.19 0.00012
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol
1.14.14.19 0.00012
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide
1.14.14.19 0.00013
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol
1.14.14.19 0.00015
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol
1.14.14.19 0.00016
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide
1.14.14.19 0.00021
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus 1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol
1.14.14.19 0.00024
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.00032
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.00034
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Homo sapiens (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.00045
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.00077
-
 in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide
1.14.14.19 0.001
-
 IC50 above 0.001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C Rattus norvegicus (+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide