BRENDA - Enzyme Database show

Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1

Wu, T.Y.; Juteau, H.; Ducharme, Y.; Friesen, R.W.; Guiral, S.; Dufresne, L.; Poirier, H.; Salem, M.; Riendeau, D.; Mancini, J.; Brideau, C.; Bioorg. Med. Chem. Lett. 20, 6978-6982 (2010)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-(4-chlorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-(4-phenoxyphenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(2-phenylethyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylethynyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfonyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-[(E)-2-phenylethenyl]phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
2-[2-(2-chloro-6-fluorophenyl)-4-[6-(phenylethynyl)pyridin-3-yl]-1H-imidazol-5-yl]ethanol
-
Homo sapiens
5.3.99.3
2-[4-(4-bromophenyl)-1H-imidazol-2-yl]benzonitrile
-
Homo sapiens
5.3.99.3
2-[4-(4-chlorophenyl)-1H-imidazol-2-yl]-3-fluorobenzonitrile
-
Homo sapiens
5.3.99.3
2-[4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)phenyl]propan-2-ol
-
Homo sapiens
5.3.99.3
3-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazole
-
Homo sapiens
5.3.99.3
4-(4-benzylphenyl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
4-(biphenyl-4-yl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzamide
-
Homo sapiens
5.3.99.3
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzoic acid
-
Homo sapiens
5.3.99.3
5-(4-bromophenyl)-3-(2-chloro-6-fluorophenyl)-1,2,4-oxadiazole
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(1,3-thiazol-2-ylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohex-1-en-1-ylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohexylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclopropylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(pyridin-3-ylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-ethynylpyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(2-chlorophenyl)ethynyl]pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(3-chlorophenyl)ethynyl]pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(4-chlorophenyl)ethynyl]pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-5-methyl-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[5-chloro-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
aminomethyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
-
Homo sapiens
5.3.99.3
methyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
A-549 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
714421
Homo sapiens
Prostaglandin E2
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.3.99.3
0.000001
-
pH and temperature not specified in the publication
Homo sapiens
5-[5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000004
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(3-chlorophenyl)ethynyl]pyridine
5.3.99.3
0.000005
-
pH and temperature not specified in the publication
Homo sapiens
5-[5-chloro-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000008
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylethynyl)phenyl]-1H-imidazole
5.3.99.3
0.000009
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(2-chlorophenyl)ethynyl]pyridine
5.3.99.3
0.000013
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohex-1-en-1-ylethynyl)pyridine
5.3.99.3
0.000016
-
pH and temperature not specified in the publication
Homo sapiens
5-[5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.00002
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-5-methyl-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000023
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000031
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(4-chlorophenyl)ethynyl]pyridine
5.3.99.3
0.000033
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohexylethynyl)pyridine
5.3.99.3
0.000035
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-[(E)-2-phenylethenyl]phenyl]-1H-imidazole
5.3.99.3
0.00011
-
pH and temperature not specified in the publication
Homo sapiens
3-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazole
5.3.99.3
0.00011
-
pH and temperature not specified in the publication
Homo sapiens
4-(biphenyl-4-yl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
5.3.99.3
0.00015
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(2-phenylethyl)phenyl]-1H-imidazole
5.3.99.3
0.00017
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclopropylethynyl)pyridine
5.3.99.3
0.00018
-
pH and temperature not specified in the publication
Homo sapiens
2-[2-(2-chloro-6-fluorophenyl)-4-[6-(phenylethynyl)pyridin-3-yl]-1H-imidazol-5-yl]ethanol
5.3.99.3
0.00018
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
5.3.99.3
0.00032
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-(4-phenoxyphenyl)-1H-imidazole
5.3.99.3
0.00048
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(pyridin-3-ylethynyl)pyridine
5.3.99.3
0.00057
-
pH and temperature not specified in the publication
Homo sapiens
4-(4-benzylphenyl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
5.3.99.3
0.00066
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-(4-chlorophenyl)-1H-imidazole
5.3.99.3
0.00094
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(1,3-thiazol-2-ylethynyl)pyridine
5.3.99.3
0.001
-
pH and temperature not specified in the publication
Homo sapiens
2-[4-(4-chlorophenyl)-1H-imidazol-2-yl]-3-fluorobenzonitrile
5.3.99.3
0.0014
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfonyl)phenyl]-1H-imidazole
5.3.99.3
0.0014
-
pH and temperature not specified in the publication
Homo sapiens
2-[4-(4-bromophenyl)-1H-imidazol-2-yl]benzonitrile
5.3.99.3
0.0025
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-ethynylpyridine
5.3.99.3
0.0037
-
pH and temperature not specified in the publication
Homo sapiens
2-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-imidazole
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
2-[4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)phenyl]propan-2-ol
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzamide
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzoic acid
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
aminomethyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
methyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
5.3.99.3
0.03
-
IC50 above 0.03 mM, pH and temperature not specified in the publication
Homo sapiens
5-(4-bromophenyl)-3-(2-chloro-6-fluorophenyl)-1,2,4-oxadiazole
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.3.99.3
0.000001
-
pH and temperature not specified in the publication
Homo sapiens
5-[5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000004
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(3-chlorophenyl)ethynyl]pyridine
5.3.99.3
0.000005
-
pH and temperature not specified in the publication
Homo sapiens
5-[5-chloro-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000008
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylethynyl)phenyl]-1H-imidazole
5.3.99.3
0.000009
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(2-chlorophenyl)ethynyl]pyridine
5.3.99.3
0.000013
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohex-1-en-1-ylethynyl)pyridine
5.3.99.3
0.000016
-
pH and temperature not specified in the publication
Homo sapiens
5-[5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.00002
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-5-methyl-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000023
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
5.3.99.3
0.000031
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(4-chlorophenyl)ethynyl]pyridine
5.3.99.3
0.000033
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohexylethynyl)pyridine
5.3.99.3
0.000035
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-[(E)-2-phenylethenyl]phenyl]-1H-imidazole
5.3.99.3
0.00011
-
pH and temperature not specified in the publication
Homo sapiens
3-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazole
5.3.99.3
0.00011
-
pH and temperature not specified in the publication
Homo sapiens
4-(biphenyl-4-yl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
5.3.99.3
0.00015
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(2-phenylethyl)phenyl]-1H-imidazole
5.3.99.3
0.00017
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclopropylethynyl)pyridine
5.3.99.3
0.00018
-
pH and temperature not specified in the publication
Homo sapiens
2-[2-(2-chloro-6-fluorophenyl)-4-[6-(phenylethynyl)pyridin-3-yl]-1H-imidazol-5-yl]ethanol
5.3.99.3
0.00018
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
5.3.99.3
0.00032
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-(4-phenoxyphenyl)-1H-imidazole
5.3.99.3
0.00048
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(pyridin-3-ylethynyl)pyridine
5.3.99.3
0.00057
-
pH and temperature not specified in the publication
Homo sapiens
4-(4-benzylphenyl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
5.3.99.3
0.00066
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-(4-chlorophenyl)-1H-imidazole
5.3.99.3
0.00094
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(1,3-thiazol-2-ylethynyl)pyridine
5.3.99.3
0.001
-
pH and temperature not specified in the publication
Homo sapiens
2-[4-(4-chlorophenyl)-1H-imidazol-2-yl]-3-fluorobenzonitrile
5.3.99.3
0.0014
-
pH and temperature not specified in the publication
Homo sapiens
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfonyl)phenyl]-1H-imidazole
5.3.99.3
0.0014
-
pH and temperature not specified in the publication
Homo sapiens
2-[4-(4-bromophenyl)-1H-imidazol-2-yl]benzonitrile
5.3.99.3
0.0025
-
pH and temperature not specified in the publication
Homo sapiens
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-ethynylpyridine
5.3.99.3
0.0037
-
pH and temperature not specified in the publication
Homo sapiens
2-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-imidazole
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
2-[4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)phenyl]propan-2-ol
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzamide
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzoic acid
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
aminomethyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
5.3.99.3
0.005
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
Homo sapiens
methyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
5.3.99.3
0.03
-
IC50 above 0.03 mM, pH and temperature not specified in the publication
Homo sapiens
5-(4-bromophenyl)-3-(2-chloro-6-fluorophenyl)-1,2,4-oxadiazole
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-(4-chlorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-(4-phenoxyphenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(2-phenylethyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylethynyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-(phenylsulfonyl)phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(2-chloro-6-fluorophenyl)-4-[4-[(E)-2-phenylethenyl]phenyl]-1H-imidazole
-
Homo sapiens
5.3.99.3
2-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
2-[2-(2-chloro-6-fluorophenyl)-4-[6-(phenylethynyl)pyridin-3-yl]-1H-imidazol-5-yl]ethanol
-
Homo sapiens
5.3.99.3
2-[4-(4-bromophenyl)-1H-imidazol-2-yl]benzonitrile
-
Homo sapiens
5.3.99.3
2-[4-(4-chlorophenyl)-1H-imidazol-2-yl]-3-fluorobenzonitrile
-
Homo sapiens
5.3.99.3
2-[4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)phenyl]propan-2-ol
-
Homo sapiens
5.3.99.3
3-(4-bromophenyl)-5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazole
-
Homo sapiens
5.3.99.3
4-(4-benzylphenyl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
4-(biphenyl-4-yl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole
-
Homo sapiens
5.3.99.3
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzamide
-
Homo sapiens
5.3.99.3
4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzoic acid
-
Homo sapiens
5.3.99.3
5-(4-bromophenyl)-3-(2-chloro-6-fluorophenyl)-1,2,4-oxadiazole
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(1,3-thiazol-2-ylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohex-1-en-1-ylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclohexylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(cyclopropylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(pyridin-3-ylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-ethynylpyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(2-chlorophenyl)ethynyl]pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(3-chlorophenyl)ethynyl]pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-[(4-chlorophenyl)ethynyl]pyridine
-
Homo sapiens
5.3.99.3
5-[2-(2-chloro-6-fluorophenyl)-5-methyl-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[5-(2-chloro-6-fluorophenyl)-1H-1,2,4-triazol-3-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
5-[5-chloro-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]-2-(phenylethynyl)pyridine
-
Homo sapiens
5.3.99.3
aminomethyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
-
Homo sapiens
5.3.99.3
methyl 4-([4-[2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl]phenyl]ethynyl)benzenesulfinate
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
A-549 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
714421
Homo sapiens
Prostaglandin E2
-
-
-
?