BRENDA - Enzyme Database show

The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model

Numao, A.; Hosono, K.; Suzuki, T.; Hayashi, I.; Uematsu, S.; Akira, S.; Ogino, Y.; Kawauchi, H.; Unno, N.; Majima, M.; Biomed. Pharmacother. 65, 77-84 (2011)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.3
medicine
mPGES-1 is a therapeutic target for endometriosis
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Mus musculus
-
Prostaglandin E2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
endometrium
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
714401
Mus musculus
Prostaglandin E2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.3
medicine
mPGES-1 is a therapeutic target for endometriosis
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Mus musculus
-
Prostaglandin E2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
endometrium
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
714401
Mus musculus
Prostaglandin E2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
the expression of vascular endothelial growth factor A is significantly reduced in mPGES-1-deficient endometrial tissues implanted into mPGES-1-deficient mice at days 14 and 28
Mus musculus
5.3.99.3
physiological function
mPGES-1 regulates growth of endometrial tissues and angiogenesis
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
the expression of vascular endothelial growth factor A is significantly reduced in mPGES-1-deficient endometrial tissues implanted into mPGES-1-deficient mice at days 14 and 28
Mus musculus
5.3.99.3
physiological function
mPGES-1 regulates growth of endometrial tissues and angiogenesis
Mus musculus