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Literature summary extracted from
- Serine racemase and the serine shuttle between neurons and astrocytes (2011), Biochim. Biophys. Acta, 1814, 1558-1566.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.1.1.18 | K56G | inactive | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.18 | aminooxyacetic acid | non-selective inhibitor | Mus musculus |  |
| 5.1.1.18 | EDTA | non-selective inhibitor | Mus musculus | |
| 5.1.1.18 | glycine | non-selective inhibitor | Mus musculus | |
| 5.1.1.18 | L-asparagine | non-selective inhibitor | Mus musculus | |
| 5.1.1.18 | L-erythro-3-hydroxyaspartate | non-selective inhibitor | Mus musculus | |
| 5.1.1.18 | malonate | non-selective inhibitor | Mus musculus | |
| 5.1.1.18 | phenazine | non-selective inhibitor | Mus musculus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.18 | Ca2+ | directly stimulates enzyme activity | Mus musculus | |
| 5.1.1.18 | Mg2+ | directly stimulates enzyme activity | Mus musculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.1.18 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.1.1.18 | astrocyte | - |
Mus musculus | - |
| 5.1.1.18 | brain | - |
Mus musculus | - |
| 5.1.1.18 | neuron | the enzyme is predominantly found in neurons | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.18 | beta-chloro-L-alanine | the artificial serine racemase substrate is degraded via alpha,beta-elimination | Mus musculus | pyruvate + NH3 + ? | - |
? | |
| 5.1.1.18 | D-serine | - |
Mus musculus | S-serine | - |
? | |
| 5.1.1.18 | L-serine | - |
Mus musculus | D-serine | - |
? | |
| 5.1.1.18 | L-serine O-sulfate | the artificial serine racemase substrate is degraded via alpha,beta-elimination | Mus musculus | pyruvate + NH3 + ? | - |
? | |
| 5.1.1.18 | L-threo-3-hydroxyaspartate | the artificial serine racemase substrate is degraded via alpha,beta-elimination | Mus musculus | pyruvate + NH3 + ? | - |
? | |
| 5.1.1.18 | L-threonine | - |
Mus musculus | ? | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.18 | ADP | - |
Mus musculus | |
| 5.1.1.18 | ATP | Mg-ATP is a stimulatory cofactor | Mus musculus | |
| 5.1.1.18 | pyridoxal 5'-phosphate | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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