BRENDA - Enzyme Database

Serine racemase and the serine shuttle between neurons and astrocytes

Wolosker, H.; Biochim. Biophys. Acta 1814, 1558-1566 (2011)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
5.1.1.18
K56G
inactive
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.1.1.18
aminooxyacetic acid
non-selective inhibitor
Mus musculus
5.1.1.18
EDTA
non-selective inhibitor
Mus musculus
5.1.1.18
glycine
non-selective inhibitor
Mus musculus
5.1.1.18
L-asparagine
non-selective inhibitor
Mus musculus
5.1.1.18
L-erythro-3-hydroxyaspartate
non-selective inhibitor
Mus musculus
5.1.1.18
malonate
non-selective inhibitor
Mus musculus
5.1.1.18
phenazine
non-selective inhibitor
Mus musculus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
5.1.1.18
Ca2+
directly stimulates enzyme activity
Mus musculus
5.1.1.18
Mg2+
directly stimulates enzyme activity
Mus musculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.1.1.18
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.1.1.18
astrocyte
-
Mus musculus
-
5.1.1.18
brain
-
Mus musculus
-
5.1.1.18
neuron
the enzyme is predominantly found in neurons
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.1.1.18
beta-chloro-L-alanine
the artificial serine racemase substrate is degraded via alpha,beta-elimination
714348
Mus musculus
pyruvate + NH3 + ?
-
-
-
?
5.1.1.18
D-serine
-
714348
Mus musculus
S-serine
-
-
-
?
5.1.1.18
L-serine
-
714348
Mus musculus
D-serine
-
-
-
?
5.1.1.18
L-serine O-sulfate
the artificial serine racemase substrate is degraded via alpha,beta-elimination
714348
Mus musculus
pyruvate + NH3 + ?
-
-
-
?
5.1.1.18
L-threo-3-hydroxyaspartate
the artificial serine racemase substrate is degraded via alpha,beta-elimination
714348
Mus musculus
pyruvate + NH3 + ?
-
-
-
?
5.1.1.18
L-threonine
-
714348
Mus musculus
?
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.1.1.18
ADP
-
Mus musculus
5.1.1.18
ATP
Mg-ATP is a stimulatory cofactor
Mus musculus
5.1.1.18
pyridoxal 5'-phosphate
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.1.1.18
ADP
-
Mus musculus
5.1.1.18
ATP
Mg-ATP is a stimulatory cofactor
Mus musculus
5.1.1.18
pyridoxal 5'-phosphate
-
Mus musculus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
5.1.1.18
K56G
inactive
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.1.1.18
aminooxyacetic acid
non-selective inhibitor
Mus musculus
5.1.1.18
EDTA
non-selective inhibitor
Mus musculus
5.1.1.18
glycine
non-selective inhibitor
Mus musculus
5.1.1.18
L-asparagine
non-selective inhibitor
Mus musculus
5.1.1.18
L-erythro-3-hydroxyaspartate
non-selective inhibitor
Mus musculus
5.1.1.18
malonate
non-selective inhibitor
Mus musculus
5.1.1.18
phenazine
non-selective inhibitor
Mus musculus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
5.1.1.18
Ca2+
directly stimulates enzyme activity
Mus musculus
5.1.1.18
Mg2+
directly stimulates enzyme activity
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.1.1.18
astrocyte
-
Mus musculus
-
5.1.1.18
brain
-
Mus musculus
-
5.1.1.18
neuron
the enzyme is predominantly found in neurons
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.1.1.18
beta-chloro-L-alanine
the artificial serine racemase substrate is degraded via alpha,beta-elimination
714348
Mus musculus
pyruvate + NH3 + ?
-
-
-
?
5.1.1.18
D-serine
-
714348
Mus musculus
S-serine
-
-
-
?
5.1.1.18
L-serine
-
714348
Mus musculus
D-serine
-
-
-
?
5.1.1.18
L-serine O-sulfate
the artificial serine racemase substrate is degraded via alpha,beta-elimination
714348
Mus musculus
pyruvate + NH3 + ?
-
-
-
?
5.1.1.18
L-threo-3-hydroxyaspartate
the artificial serine racemase substrate is degraded via alpha,beta-elimination
714348
Mus musculus
pyruvate + NH3 + ?
-
-
-
?
5.1.1.18
L-threonine
-
714348
Mus musculus
?
-
-
-
?