Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Brown-Marshall, C.D.; Diebold, A.R.; Solomon, E.I.
    Reaction coordinate of isopenicillin N synthase: oxidase versus oxygenase activity (2010), Biochemistry, 49, 1176-1182.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.1 Aspergillus nidulans
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O the hydroperoxide-ferrous intermediate, formed by O2-activated H atom abstraction from the substrate, can exploit different reaction pathways and interactions with the substrate govern the final pathway Aspergillus nidulans
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.1 delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-hydroxyisovaleryl ester + O2 for this substrate analogue (ACOV) lacking an amide nitrogen IPNS exhibits oxygenase activity Aspergillus nidulans ?
-
 ?
1.21.3.1 delta-L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2 for the native substrate IPNS shows oxidase activity Aspergillus nidulans isopenicillin N + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.3.1 IPNS
-
 Aspergillus nidulans
1.21.3.1 isopenicillin N synthase
-
 Aspergillus nidulans