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Literature summary extracted from

  • Maiti, P.; Kong, J.; Kim, S.R.; Sparrow, J.R.; Allikmets, R.; Rando, R.R.
    Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation (2006), Biochemistry, 45, 852-860.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.64 additional information 13,17,21-trimethyldocosa-12,16,20-trien-11-one and 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide are potent mRPE65 antagonists that inhibit 11-cis-retinal regeneration Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.64 membrane
-
 Bos taurus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.64 all-trans-retinyl ester + H2O Bos taurus
-
 11-cis-retinol + a fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.64 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.64
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.64 optic cup
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.64 all-trans-retinyl ester + H2O
-
 Bos taurus 11-cis-retinol + a fatty acid
-
 ?
3.1.1.64 all-trans-retinyl palmitate + H2O
-
 Bos taurus 11-cis-retinol + palmitate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.64 Rpe65
-
 Bos taurus

General Information

EC Number General Information Comment Organism
3.1.1.64 physiological function RPE65 is essential for the operation of the visual cycle. RPE65 is also on the rate-limiting pathway to fluorophore A2E (lipofuscin) formation Bos taurus