BRENDA - Enzyme Database show

RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters

Gollapalli, D.R.; Maiti, P.; Rando, R.R.; Biochemistry 42, 11824-11830 (2003)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.1.64
membrane
-
Bos taurus
16020
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.64
Bos taurus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.1.1.64
DEAE-Sepharose column chromatography and phenyl-Sepharose CL-4B column chromatography
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.64
retinal pigment epithelial cell
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.64
all-trans-retinyl ester + H2O
-
714150
Bos taurus
11-cis-retinol + a fatty acid
-
-
-
?
3.1.1.64
all-trans-retinyl palmitate + H2O
high binding affinity
714150
Bos taurus
11-cis-retinol + palmitate
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
3.1.1.64
?
x * about 60000, SDS-PAGE
Bos taurus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.1.64
membrane
-
Bos taurus
16020
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.1.64
DEAE-Sepharose column chromatography and phenyl-Sepharose CL-4B column chromatography
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.64
retinal pigment epithelial cell
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.64
all-trans-retinyl ester + H2O
-
714150
Bos taurus
11-cis-retinol + a fatty acid
-
-
-
?
3.1.1.64
all-trans-retinyl palmitate + H2O
high binding affinity
714150
Bos taurus
11-cis-retinol + palmitate
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.1.1.64
?
x * about 60000, SDS-PAGE
Bos taurus
General Information
EC Number
General Information
Commentary
Organism
3.1.1.64
physiological function
RPE65 functions by binding to and mobilizing the highly hydrophobic all-trans-retinyl esters, allowing them to enter the visual cycle
Bos taurus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.1.64
physiological function
RPE65 functions by binding to and mobilizing the highly hydrophobic all-trans-retinyl esters, allowing them to enter the visual cycle
Bos taurus