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Literature summary extracted from

  • Gollapalli, D.R.; Maiti, P.; Rando, R.R.
    RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters (2003), Biochemistry, 42, 11824-11830.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.64 membrane
-
 Bos taurus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.64 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.64 DEAE-Sepharose column chromatography and phenyl-Sepharose CL-4B column chromatography Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.64 retinal pigment epithelial cell
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.64 all-trans-retinyl ester + H2O
-
 Bos taurus 11-cis-retinol + a fatty acid
-
 ?
3.1.1.64 all-trans-retinyl palmitate + H2O high binding affinity Bos taurus 11-cis-retinol + palmitate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.64 ? x * about 60000, SDS-PAGE Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.64 isomerohydrolase
-
 Bos taurus
3.1.1.64 Rpe65
-
 Bos taurus

General Information

EC Number General Information Comment Organism
3.1.1.64 physiological function RPE65 functions by binding to and mobilizing the highly hydrophobic all-trans-retinyl esters, allowing them to enter the visual cycle Bos taurus