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Literature summary extracted from
- Inhibition of cyclooxygenase activity of prostaglandin-H-synthase by excess substrate (molecular oxygen) (2010), Biochemistry (Moscow), 75, 1368-1373.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | O2 | the cyclooxygenase reaction is inhibited by an excess of dissolved oxygen, 0.5 mM O2 causes twofold decrease in the initial rate and maximal yield | Ovis aries |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.99.1 | additional information | - |
additional information | the cyclooxygenase reaction shows Michaelis-Menten kinetics over a wide range of oxygen concentrations in the absence of electron donor. Kinetics analysis, overview | Ovis aries |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.99.1 | microsome | - |
Ovis aries | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + 2 O2 | Ovis aries | - |
prostaglandin G2 | - |
? | |
| 1.14.99.1 | prostaglandin G2 + AH2 | Ovis aries | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | Ovis aries | - |
male | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | vesicular gland | - |
Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + 2 O2 | - |
Ovis aries | prostaglandin G2 | - |
? | |
| 1.14.99.1 | additional information | maximal values of the initial reaction rate and yield of the product are attained at oxygen concentration 0.05 mM | Ovis aries | ? | - |
? | |
| 1.14.99.1 | prostaglandin G2 + AH2 | - |
Ovis aries | prostaglandin H2 + A + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | cyclooxygenase | - |
Ovis aries |
| 1.14.99.1 | PGHS | - |
Ovis aries |
| 1.14.99.1 | prostaglandin-H-synthase | - |
Ovis aries |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.1 | 25 | - |
assay at | Ovis aries |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.1 | 8 | - |
assay at | Ovis aries |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | metabolism | the enzyme catalyzes the committed step in prostaglandin biosynthesis | Ovis aries |
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Release 2023.1 (January 2023)
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