EC Number | Application | Comment | Organism |
---|---|---|---|
3.1.8.1 | medicine | PON1 shows potential as a prophylactic treatment against tabun exposure | Homo sapiens |
3.1.8.1 | medicine | PON1 shows potential as a prophylactic treatment against tabun exposure | Oryctolagus cuniculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.2 | expressed in Trichoplusia ni larvae | Homo sapiens |
3.1.8.1 | expressed in Trichoplusia ni larvae | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.2 | 2-hydroxyquinoline | specific paraoxonase 1 inhibitor, dose-dependent inhibition | Homo sapiens | |
3.1.1.2 | 2-hydroxyquinoline | specific paraoxonase 1 inhibitor, dose-dependent inhibition | Oryctolagus cuniculus | |
3.1.8.1 | 2-hydroxyquinoline | specific paraoxonase 1 inhibitor, dose-dependent inhibition | Homo sapiens | |
3.1.8.1 | 2-hydroxyquinoline | specific paraoxonase 1 inhibitor, dose-dependent inhibition | Oryctolagus cuniculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.2 | Homo sapiens | - |
- |
- |
3.1.1.2 | Oryctolagus cuniculus | - |
- |
- |
3.1.8.1 | Homo sapiens | - |
- |
- |
3.1.8.1 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.1.2 | DEAE-Sepharose column chromatography, Concanavalin A-Sepharose column chromatography, and Sepharose CL-6B gel filtration | Homo sapiens |
3.1.1.2 | DEAE-Sepharose column chromatography, Concanavalin A-Sepharose column chromatography, and Sepharose CL-6B gel filtration | Oryctolagus cuniculus |
3.1.8.1 | DEAE-Sepharose column chromatography, Concanavalin A-Sepharose column chromatography, and Sepharose CL-6B gel filtration | Homo sapiens |
3.1.8.1 | DEAE-Sepharose column chromatography, Concanavalin A-Sepharose column chromatography, and Sepharose CL-6B gel filtration | Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.2 | serum | - |
Homo sapiens | - |
3.1.1.2 | serum | - |
Oryctolagus cuniculus | - |
3.1.8.1 | serum | - |
Homo sapiens | - |
3.1.8.1 | serum | - |
Oryctolagus cuniculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.1.1.2 | 3.5 | - |
enzyme purified from serum, in 20 mM Tris-HCl buffer (pH 7.4), at 37°C | Homo sapiens |
3.1.1.2 | 3.5 | - |
enzyme purified from serum, in 20 mM Tris-HCl buffer (pH 7.4), at 37°C | Oryctolagus cuniculus |
3.1.1.2 | 8.5 | - |
recombinant enzyme, after purification, in 20 mM Tris-HCl buffer (pH 7.4), at 37°C | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.2 | 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
3.1.1.2 | 4-nitrophenyl acetate + H2O | - |
Oryctolagus cuniculus | 4-nitrophenol + acetate | - |
? | |
3.1.8.1 | diisopropyl fluorophosphate + H2O | - |
Homo sapiens | ? | - |
? | |
3.1.8.1 | diisopropyl fluorophosphate + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.1.8.1 | sarin + H2O | efficient hydrolysis of sarin (11 nM) is observed with about 0.08-0.25 units of paraoxonase 1 | Homo sapiens | ? | - |
? | |
3.1.8.1 | sarin + H2O | efficient hydrolysis of sarin (11 nM) is observed with about 0.08-0.25 units of paraoxonase 1 | Oryctolagus cuniculus | ? | - |
? | |
3.1.8.1 | soman + H2O | efficient hydrolysis of soman (3 nM) is observed with about 0.08-0.25 units of paraoxonase 1 | Homo sapiens | ? | - |
? | |
3.1.8.1 | soman + H2O | efficient hydrolysis of soman (3 nM) is observed with about 0.08-0.25 units of paraoxonase 1 | Oryctolagus cuniculus | ? | - |
? | |
3.1.8.1 | tabun + H2O | efficient hydrolysis of tabun (100 nM) is observed with about 0.025-0.04 units of paraoxonase 1. Tabun hydrolysis with paraoxonase 1 is about 30-60times and about 200-260times more efficient than that with sarin and soman, respectively | Homo sapiens | ? | - |
? | |
3.1.8.1 | tabun + H2O | efficient hydrolysis of tabun (100 nM) is observed with about 0.025-0.04 units of paraoxonase 1. Tabun hydrolysis with paraoxonase 1 is about 30-60times and about 200-260times more efficient than that with sarin and soman, respectively | Oryctolagus cuniculus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.1.2 | ? | x * 40000-45000, paraoxonase 1 is separated as three bands with an approximate molecular weight of 40000-45000 Da, SDS-PAGE | Homo sapiens |
3.1.1.2 | ? | x * 40000-45000, paraoxonase 1 is separated as three bands with an approximate molecular weight of 40000-45000 Da, SDS-PAGE | Oryctolagus cuniculus |
3.1.8.1 | ? | x * 40000-45000, paraoxonase 1 is separated as three bands with an approximate molecular weight of 40000-45000 Da, SDS-PAGE | Homo sapiens |
3.1.8.1 | ? | x * 40000-45000, paraoxonase 1 is separated as three bands with an approximate molecular weight of 40000-45000 Da, SDS-PAGE | Oryctolagus cuniculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.8.1 | physiological function | paraoxonase 1 functions as an efficient catalytic bioscavenger against nerve agents | Homo sapiens |
3.1.8.1 | physiological function | paraoxonase 1 functions as an efficient catalytic bioscavenger against nerve agents | Oryctolagus cuniculus |