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Literature summary extracted from

  • Daubner, S.C.; Le, T.; Wang, S.
    Tyrosine hydroxylase and regulation of dopamine synthesis (2011), Arch. Biochem. Biophys., 508, 1-12.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.16.2 DELTA1-120 not inhibited by dopamine Rattus norvegicus
1.14.16.2 DELTA1-32 90% inhibited by dopamine Rattus norvegicus
1.14.16.2 DELTA1-68 not inhibited by dopamine Rattus norvegicus
1.14.16.2 DELTA1-76 not inhibited by dopamine Rattus norvegicus
1.14.16.2 S19E investigation of regulation by phosphorylation Rattus norvegicus
1.14.16.2 S19E/S40E investigation of regulation by phosphorylation, slight decrease in KM value for tetrahydrobiopterin, slight increase in Vmax value Rattus norvegicus
1.14.16.2 S31E good mimic of phosphorylated wild type protein Rattus norvegicus
1.14.16.2 S40E good mimic of phosphorylated wild type protein Rattus norvegicus
1.14.16.2 S8E investigation of regulation by phosphorylation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 dopamine feedback inhibitor, competitively with tetrahydrobiopterin Rattus norvegicus
1.14.16.2 epinephrine feedback inhibitor Rattus norvegicus
1.14.16.2 norepinephrine feedback inhibitor Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.16.2 Iron
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 tyrosine hydroxylase
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.14.16.2 metabolism rate-limiting enzyme of catecholamine biosynthesis, regulated by phosphorylation, phosphorylation of Ser40 results in a decrease in affinity for catecholamines, phosphorylation of Ser31 results in a decrease in KM value for tetrahydrobiopterin, modified in the presence of NO, resulting in nitration of tyrosine residues (loss of activity) and the glutathionylation of cysteine residues Rattus norvegicus