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Literature summary extracted from

  • Chatterjee, A.; Hazra, A.B.; Abdelwahed, S.; Hilmey, D.G.; Begley, T.P.
    A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase (2010), Angew. Chem. Int. Ed. Engl., 49, 8653-8656.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.99.17 iron-sulfur centre
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Bacteria

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine Bacteria the enzyme is involved in thiamine biosynthesis 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
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?

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.17 Bacteria
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO mechanistic analysis Bacteria

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine the enzyme is involved in thiamine biosynthesis Bacteria 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
?
4.1.99.17 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine mechanistic analysis Bacteria 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
?

General Information

EC Number General Information Comment Organism
4.1.99.17 physiological function the enzyme is involved in thiamine biosynthesis Bacteria