BRENDA - Enzyme Database show

Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers

Ae, T.; Ohno, T.; Hattori, Y.; Suzuki, T.; Hosono, K.; Minamino, T.; Sato, T.; Uematsu, S.; Akira, S.; Koizumi, W.; Majima, M.; Am. J. Physiol. Gastrointest. Liver Physiol. 299, G1139-G1146 (2010)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Mus musculus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Mus musculus
-
Prostaglandin E2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
stomach
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
713719
Mus musculus
Prostaglandin E2
-
-
-
?
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Mus musculus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Mus musculus
-
Prostaglandin E2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
stomach
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
713719
Mus musculus
Prostaglandin E2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
the expression of mPGES-1 in wild type mice is markedly upregulated in the gastric ulcer tissues compared with normal gastric tissues without ulcers
up
General Information
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
the healing of acetic acid-induced gastric ulcers is significantly delayed in mPGES-1 knockout mice compared with wild type. This is accompanied with reduced angiogenesis in ulcer granulation tissues. The mRNA levels of proangiogenic growth factors, such as transforming growth factor-beta, basic fibroblast growth factor, and connective tissue growth factor are reduced in mPGES-1 knockout mice compared with wild type
Mus musculus
5.3.99.3
physiological function
mPGES-1 enhances the gastric ulcer-healing processes and the angiogenesis indispensable to gastric ulcer healing
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
the healing of acetic acid-induced gastric ulcers is significantly delayed in mPGES-1 knockout mice compared with wild type. This is accompanied with reduced angiogenesis in ulcer granulation tissues. The mRNA levels of proangiogenic growth factors, such as transforming growth factor-beta, basic fibroblast growth factor, and connective tissue growth factor are reduced in mPGES-1 knockout mice compared with wild type
Mus musculus
5.3.99.3
physiological function
mPGES-1 enhances the gastric ulcer-healing processes and the angiogenesis indispensable to gastric ulcer healing
Mus musculus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
the expression of mPGES-1 in wild type mice is markedly upregulated in the gastric ulcer tissues compared with normal gastric tissues without ulcers
up