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Literature summary extracted from
- Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing (2010), PLoS ONE, 5, e11497.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.4.12 | expressed in Escherichia coli BL21(DE3) and in HEK-293 cells | Mus musculus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.12 | cytosol | - |
Mus musculus | 5829 | - |
| 1.8.4.12 | nucleus | - |
Mus musculus | 5634 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.12 | 5000 | - |
MsrB1 occurs in two protein forms that migrate as 14000 and 5000 Da proteins, SDS-PAGE | Mus musculus |
| 1.8.4.12 | 14000 | - |
MsrB1 occurs in two protein forms that migrate as 14000 and 5000 Da proteins, SDS-PAGE | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.12 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.4.12 | Talon Co2+ affinity resin column chromatography | Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.12 | brain | - |
Mus musculus | - |
| 1.8.4.12 | heart | - |
Mus musculus | - |
| 1.8.4.12 | kidney | - |
Mus musculus | - |
| 1.8.4.12 | liver | highest expression | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.12 | dabsyl-L-methionine (R)-sulfoxide + dithiothreitol | - |
Mus musculus | dabsyl-L-methionine + dithiothreitol disulfide + H2O | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.12 | methionine sulfoxide reductase B1 | - |
Mus musculus |
| 1.8.4.12 | MSRB1 | previously known as SelR or SelX | Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.12 | thioredoxin | - |
Mus musculus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.8.4.12 | physiological function | oxidative stress can lead to oxidation of methionine residues, which are repaired by MsrB1 | Mus musculus |
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Release 2023.1 (January 2023)
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